Journal ArticleDOI
Polyion Complex Micelles with Reactive Aldehyde Groups on Their Surface from Plasmid DNA and End-Functionalized Charged Block Copolymers
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This article is published in Macromolecules.The article was published on 1999-09-11. It has received 88 citations till now. The article focuses on the topics: Micelle.read more
Citations
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Journal ArticleDOI
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
Journal ArticleDOI
Micellization of block copolymers
TL;DR: A general overview of the preparation, characterization and theories of block copolymer micellar systems is presented in this paper, with examples of micelle formation in aqueous and organic medium are given for di-and triblock copolymers, as well as for more complex architectures.
Journal ArticleDOI
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
TL;DR: The potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications.
Journal ArticleDOI
Block copolymer micelles for delivery of gene and related compounds.
TL;DR: The synthesis of block copolymers as well as graftCopolymers utilized as DNA delivery systems are described and particular emphasis is devoted to the association behavior and the physicochemical properties of polyion complex micelles entrapping DNA and related substances in relation to the biological aspects of the associates.
Journal ArticleDOI
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications
TL;DR: A State-of-the-art use of PEG in therapeutic applications, its clinical status and commercial use is summarized, and toxicities related to different PEG grades and related impurities are discussed in this review.
References
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Journal ArticleDOI
Analysis of Macromolecular Polydispersity in Intensity Correlation Spectroscopy: The Method of Cumulants
TL;DR: The first order electric field correlation function of laser light scattered by polydisperse solutions of macromolecules can be written as a sum or distribution of exponentials, with decay rates proportional to the diffusion coefficients of the solute molecules as discussed by the authors.
Journal ArticleDOI
Formation of Polyion Complex Micelles in an Aqueous Milieu from a Pair of Oppositely-Charged Block Copolymers with Poly(ethylene glycol) Segments
Atsushi Harada,Kazunori Kataoka +1 more
TL;DR: In this paper, stable and monodispersive polyion complex micelles were prepared in an aqueous milieu through electrostatic interaction between a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments.
Journal ArticleDOI
Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers
Atsushi Harada,Kazunori Kataoka +1 more
TL;DR: Molecular recognition based on length was found to occur between oppositely charged pairs of flexible and randomly coiled block copolymers in an aqueous milieu.
Journal ArticleDOI
Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer
TL;DR: The profile of the thermal melting curve revealed a higher stabilization of DNA structure in PEG-PLL/DNA complexes compared to that in the complex made from DNA and PLL homopolymer with the same molecular weight, suggesting DNA protection through the segregation into the core of the associate having PEG palisade.
Journal ArticleDOI
Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium
Atsushi Harada,Kazunori Kataoka +1 more
TL;DR: A core−shell-type supramolecular assembly, a polyion complex micelle, was prepared from chicken egg white lysozyme and poly(ethylene glycol)−poly(aspartic acid) block copolymer through electrostatic interaction in aqueous medium and no precipitate formation was observed even after 1 month standing at ambient temperature, suggesting that the system is in a thermodynamic equilibrium state.
Related Papers (5)
Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer
Formation of Polyion Complex Micelles in an Aqueous Milieu from a Pair of Oppositely-Charged Block Copolymers with Poly(ethylene glycol) Segments
Atsushi Harada,Kazunori Kataoka +1 more
Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers
Atsushi Harada,Kazunori Kataoka +1 more