Journal ArticleDOI
Polymer Micelles Stabilization on Demand through Reversible Photo-Cross-Linking
Reads0
Chats0
TLDR
The stability of polymer micelles, which affects the stability of encapsulation of guest molecules, may be a crucial condition for some controlled delivery applications, and it is possible that polymer mouselles are disintegrated after being administrated in the body due to an extreme dilution to below the critical micelle concentration of the polymer.Abstract:
The stability of polymer micelles, which affects the stability of encapsulation of guest molecules, may be a crucial condition for some controlled delivery applications. It is possible that polymer micelles are disintegrated after being administrated in the body due to an extreme dilution to below the critical micelle concentration of the polymer. If this happens, the entrapped guest such as a drug can leak out quickly, which renders any strategy for site-specific transport of the micelles useless. 1read more
Citations
More filters
Journal ArticleDOI
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Mahdi Karimi,Amir Ghasemi,Parham Sahandi Zangabad,Reza Rahighi,S. Masoud Moosavi Basri,S. Masoud Moosavi Basri,Hamed Mirshekari,Mandana Amiri,Z. Shafaei Pishabad,A. Aslani,Mahnaz Bozorgomid,Deepanjan Ghosh,Ali Beyzavi,A. Vaseghi,Amir Reza Aref,L. Haghani,Sajad Bahrami,Michael R. Hamblin,Michael R. Hamblin +18 more
TL;DR: This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
Journal ArticleDOI
ATRP in the design of functional materials for biomedical applications
TL;DR: Recent advances in the preparation of polymer-based nanomaterials using ATRP are reviewed, including polymer bioconjugates, block copolymer-based drug delivery systems, cross-linked microgels/nanogels, diagnostic and imaging platforms, tissue engineering hydrogels, and degradable polymers.
Journal ArticleDOI
Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Ja-Hyoung Ryu,Reuben T. Chacko,Siriporn Jiwpanich,Sean Bickerton,R. Prakash Babu,Sankaran Thayumanavan +5 more
TL;DR: Highly stable polymeric nanogels are synthesized, in which the kinetics of guest molecule release can be fine-tuned by control over cross-linking density, and it is shown that the noncovalently encapsulated guest molecules can be released in response to a redox trigger, glutathione (GSH).
Journal ArticleDOI
Light-Responsive Block Copolymer Micelles
TL;DR: The different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles are discussed.
Journal ArticleDOI
Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery.
TL;DR: A variety of mechanisms have recently been described to accomplish the destabilisation of polymeric micelles and vesicles by temperature, pH, chemical or enzymatic hydrolysis of side chains, oxidation/reduction processes, and light.
References
More filters
Journal ArticleDOI
Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica
TL;DR: It is shown that the uptake, storage and release of organic molecules in MCM-41 can be regulated through the photocontrolled and reversible intermolecular dimerization of coumarin derivatives attached to the pore outlets.
Journal ArticleDOI
Coumarins in polymers: From light harvesting to photo-cross-linkable tissue scaffolds
Journal ArticleDOI
Water-Soluble Knedel-like Structures: The Preparation of Shell-Cross-Linked Small Particles
Journal ArticleDOI
A new design for light-breakable polymer micelles.
Jinqiang Jiang,Xia Tong,Yue Zhao +2 more
TL;DR: Upon UV light irradiation of polymer micellar solutions, the photosolvolysis of pyrene moieties results in their detachment from the polymer and converts the hydrophobic PPy block into hydrophilic poly(methacrylic acid).
Journal ArticleDOI
Preparation of Azobenzene-Containing Amphiphilic Diblock Copolymers for Light-Responsive Micellar Aggregates
Guang Wang,Xia Tong,Yue Zhao +2 more
TL;DR: In this article, diblock copolymers composed of a side-chain liquid crystalline azobenzene-containing polymethacrylate and poly(tert-butyl acrylate) (PAzoMA-b-PtBA) were prepared using atom-transfer radical polymerization (ATRP).