Polymeric scaffolds in tissue engineering application: a review
Reads0
Chats0
TLDR
An overview of the different types of scaffolds with their material properties is discussed and the fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.Abstract:
Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.read more
Citations
More filters
Journal ArticleDOI
3D Composite Assemblies of Microparticles and Nanofibers for Tailored Wettability and Controlled Drug Delivery
Nicolas Lavielle,Nicolas Lavielle,Anne Hébraud,Linda Thöny-Meyer,René M. Rossi,Guy Schlatter +5 more
TL;DR: Sandwich-like nanofibrous membranes with dye-loaded PLA nanoparticles confined between two PLA nan ofibrous layers are also envisaged for tailored temporal drug delivery.
Journal ArticleDOI
[Biodegradablescaffolds based on chitosan: Preparation, properties, and use for the cultivation of animal cells].
N. R. Kil’deeva,M. A. Kasatkina,M. Drozdova,Tatiana S. Demina,S. A. Uspenskii,Sergey N. Mikhailov,Elena Markvicheva +6 more
TL;DR: Using the L929 mouse fibroblasts model line, it is demonstrated that scaffolds based on chitosan with a molecular weight of 320 and 190 kDa crosslinked with genipin and GA are biocompatible and the cells are uniformly distributed in all scaffold samples.
Journal ArticleDOI
Extraordinary biological properties of a new calcium hydroxyapatite/poly(lactide-co-glycolide)-based scaffold confirmed by in vivo investigation.
Vukoman Jokanović,Božana Čolović,Dejan Markovic,Milan Petrovic,Ivan Soldatovic,Djordje Antonijevic,Petar Milosavljević,Nikola Sjerobabin,Jelena Sopta +8 more
TL;DR: All biofunctionality assays proved the new scaffold’s suitability as a bone substitute for applications in maxillofacial surgery, reflected mainly as a lower number of giant cells surrounding implanted material and higher degree of mineralization in new formed bone.
Journal ArticleDOI
Enhancement in ageing and functional properties of copper-coated fabrics by subsequent electroplating
TL;DR: In this paper, a simple way to prepare electrically conductive multifunctional fabrics made by imparting copper nanoparticles and followed with copper electroplating was proposed, and the surface and ageing properties of such fabrics were investigated.
Journal ArticleDOI
Polylactide- and polycaprolactone-based substrates enhance angiogenic potential of human umbilical cord-derived mesenchymal stem cells in vitro - implications for cardiovascular repair.
Malgorzata Sekula,Patrycja Domalik-Pyzik,A. Morawska-Chochół,Sylwia Bobis-Wozowicz,Elżbieta Karnas,Sylwia Noga,Dariusz Boruczkowski,Marta Adamiak,Zbigniew Madeja,Jan Chłopek,Ewa K. Zuba-Surma +10 more
TL;DR: PLA and PCL enhance selected biological properties of hUC-MSCs essential for their regenerative capacity including migratory and proangiogenic potential, which are required for effective vascular repair in vivo, which may be potentially employed as future novel grafts in tissue regeneration such as blood vessel reconstruction.
References
More filters
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal ArticleDOI
Biodegradable polymers as biomaterials
TL;DR: This review summarizes the main advances published over the last 15 years, outlining the synthesis, biodegradability and biomedical applications ofBiodegradable synthetic and natural polymers.
Journal ArticleDOI
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.