Journal ArticleDOI
Positive relationship between the nocturnal concentrations of melatonin and prolactin, and a stimulation of prolactin after melatonin administration in young men.
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TLDR
Evidence is provided for melatonin controlling the nocturnal increase of prolactin via its ability to stimulate prolactIn release and oral administration of 6 mg melatonin significantly stimulated prolact in release above concentrations measured after placebo administration in both the morning and evening time periods.Abstract:
The relationship between the concentrations of melatonin and prolactin over the 24-h cycle has been investigated in a group of young men at three times in the year. Melatonin and prolactin showed a significant positive correlation (P less than 0.001) for all times during the 24-h period but with a greater contribution from concentrations during the nocturnal period, when both hormones were elevated. The positive correlation for nocturnal concentrations was evident in February and March (P less than 0.01) but was of greatest significance in June (P less than 0.001). In blood samples taken at 15-min intervals during the morning (0800-1200) and evening (2000-2400), melatonin and prolactin concentrations were not significantly correlated. Melatonin concentrations increased before prolactin during the evening and decreased before prolactin in the morning. Oral administration of 6 mg melatonin significantly stimulated prolactin release above concentrations measured after placebo administration, in both the morning (P less than 0.05) and evening (P less than 0.01) time periods; the prolactin response being greater in the evening. These results provide evidence for melatonin controlling the nocturnal increase of prolactin via its ability to stimulate prolactin release.read more
Citations
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Journal ArticleDOI
Melatonin and the reduction or alleviation of stress.
TL;DR: It was noted that melatonin reduces or alleviates the stress associated with the simulated eastward travel and stress reduction in the melatonin group was supported by results from the profile of moods state questionnaire.
Patent
Methods for treating circadian rhythm disorders
Alfred J. Lewy,Robert L. Sack +1 more
TL;DR: In this article, a method for treating circadian rhythm disorders is described, which involves the administration of melatonin, melatonin agonists or compounds that stimulate endogenous melatonin production so that the durations of the effective plasma concentrations of the medications overlap with the onset or offset of pre-treatment endogenous melanoma production, to provide a circadian-rhythm phase advance or phase delay.
Journal ArticleDOI
Melatonin regulates somatotrope and lactotrope function through common and distinct signaling pathways in cultured primary pituitary cells from female primates.
Alejandro Ibáñez-Costa,Jose Cordoba-Chacon,Jose Cordoba-Chacon,Manuel D. Gahete,Rhonda D. Kineman,Justo P. Castaño,Raúl M. Luque +6 more
TL;DR: Results show, for the first time in a primate model, that MT directly regulates somatotrope/lactotroPE function, thereby lending support to the notion that the actions of MT on these cells might substantially contribute to the define daily patterns of GH and PRL observed in primates and perhaps in humans.
Journal ArticleDOI
Melatonin, Receptors, Mechanism, and Uses
Syed Haris Omar,Nabi Saba +1 more
TL;DR: Primary clinical uses include the regulation of circadian rhythms and sleep disorders, although it has other endocrine, immunomodulatory, and oncostatic effects.
Journal ArticleDOI
Amplification of nocturnal melatonin secretion in women with nocturnal hyperprolactinemia.
TL;DR: In this article, the authors assess the role of melatonin (MLT) in nocturnal hyperprolactinemia (NH), and find that the abnormal PRL release in patients with NH is not due to higher sensitivity to MLT.
References
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The Pineal and Its Hormones in the Control of Reproduction in Mammals
TL;DR: By the usual criteria in endocrinology, the pineal now fulfills all the qualifications of an organ of internal secretion.
Book ChapterDOI
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Journal ArticleDOI
Human prolactin - 24-hour pattern with increased release during sleep.
TL;DR: A marked diurnal variation in plasma concentrations was demonstrated, with highest values during sleep; periods of episodic release occurred throughout the 24 hours.
Journal ArticleDOI
Effect of melatonin on the reproductive systems of male and female Syrian hamsters: a diurnal rhythm in sensitivity to melatonin.
TL;DR: It is indicated that chronic daily injections of melatonin can depress reproductive function in hamsters and that the effectiveness of the injections is dependent upon the time of day at which they are administered.
Journal ArticleDOI
Effects of melatonin and serotonin on the release of FSH and prolactin.
TL;DR: Melatonin as well as serotonin, when injected into the third ventricle of the brain of male rats, appeared to stimulate the release of prolactin and inhibit the releaseof FSH as judged by the changes in the concentrations of these hormones in the plasma of the recipient animals.