Journal ArticleDOI
Positive relationship between the nocturnal concentrations of melatonin and prolactin, and a stimulation of prolactin after melatonin administration in young men.
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TLDR
Evidence is provided for melatonin controlling the nocturnal increase of prolactin via its ability to stimulate prolactIn release and oral administration of 6 mg melatonin significantly stimulated prolact in release above concentrations measured after placebo administration in both the morning and evening time periods.Abstract:
The relationship between the concentrations of melatonin and prolactin over the 24-h cycle has been investigated in a group of young men at three times in the year. Melatonin and prolactin showed a significant positive correlation (P less than 0.001) for all times during the 24-h period but with a greater contribution from concentrations during the nocturnal period, when both hormones were elevated. The positive correlation for nocturnal concentrations was evident in February and March (P less than 0.01) but was of greatest significance in June (P less than 0.001). In blood samples taken at 15-min intervals during the morning (0800-1200) and evening (2000-2400), melatonin and prolactin concentrations were not significantly correlated. Melatonin concentrations increased before prolactin during the evening and decreased before prolactin in the morning. Oral administration of 6 mg melatonin significantly stimulated prolactin release above concentrations measured after placebo administration, in both the morning (P less than 0.05) and evening (P less than 0.01) time periods; the prolactin response being greater in the evening. These results provide evidence for melatonin controlling the nocturnal increase of prolactin via its ability to stimulate prolactin release.read more
Citations
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Journal ArticleDOI
Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.
Rachel Leproult,Rachel Leproult,Anne Van Onderbergen,Mireille L’Hermite-Balériaux,Eve Van Cauter,Georges Copinschi +5 more
TL;DR: Whether the potent melatonin agonist agomelatine (S‐20098) is capable of phase‐shifting overt circadian rhythms in older adults is investigated.
Journal ArticleDOI
Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects.
TL;DR: The melatonin measures were not consistently related to any of the previously reported hypothalamic-pituitary-adrenal cortical axis measures in these subjects, and failed to confirm a "low melatonin syndrome" or an inverse relationship between nocturnal melatonin andnocturnal cortisol concentrations in depression.
Journal ArticleDOI
Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence.
Hope Foley,Amie Steel +1 more
TL;DR: Oral melatonin supplementation in humans has a generally favourable safety profile with some exceptions, and most adverse effects can likely be easily avoided or managed by dosing in accordance with natural circadian rhythms.
Journal ArticleDOI
The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice
TL;DR: The hypothesis that the pineal gland can exaggerate the development of CIA via a high release of melatonin, probably via enhancement of T-cell priming is supported.
Journal ArticleDOI
Melatonin hormone profile in infertile males
TL;DR: Low levels of melatonin in semen were observed in infertile groups having reduced sperm motility, leucocytospermia, varicocele and NOA, suggesting that melatonin may be involved in the modulation of reproductive neuroendocrine axis in male infertility.
References
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Journal ArticleDOI
Circadian and circannual rhythms in plasma hormones and other variables of five healthy young human males.
Alain Reinberg,Michel Lagoguey,François Cesselin,Yvan Touitou,Jean-Claude Legrand,Annick Delassalle,Joséphine Antreassian,Alenka Lagoguey +7 more
TL;DR: In this article, every other month (plasma) and every month (urine) circadian rhythms were documented during the course of 14 months, and annual changes were validated in the 24-hour mean of: plasma FSH (annual crest time: February), LH (March), thyroxine (September), cortisol (February), renin activity (April), testosterone (October), urinary 17-hydroxycorticosteroids (March, aldosterone ( March), potassium (May), as well as sexual activity (September) [self-recorded daily].
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Patterns of plasma melatonin with ageing and mental condition: stability of nyctohemeral rhythms and differences in seasonal variations
TL;DR: The stability of the nyctohemeral peak time whatever the age group or season as opposed to the differences in the seasonal pattern of plasma melatonin according to the age groups raises the problems of both outdoor photoperiod and ageing in ruling the secretion of melatonin in man.
Journal ArticleDOI
Plasma melatonin increases during exercise in women.
Daniel B. Carr,Steven M. Reppert,Beverly A. Bullen,Gary S. Skrinar,Inese Z. Beitins,Michael A. Arnold,Michael Rosenblatt,J. B. Martin,J. W. McArthur +8 more
TL;DR: This finding indicates that vigorous physical activity elicits transient increases in plasma melatonin in both sedentary and trained women.
Journal ArticleDOI
Validation of a sensitive direct assay for melatonin for investigation of circadian rhythms in different species.
TL;DR: Melatonin concentrations in the assay were evaluated by four different methods: UV absorbance, gas chromatography, comparison of the immunoreactive concentrations of the label with the expected concentration by dilution and by comparison with a previously established assay which uses the same antiserum.
Journal ArticleDOI
Long-term studies on immunoreactive human melatonin.
TL;DR: Intra-individual variations are seen at different times of the year at 2400 and 0800, with low values in spring and autumn and high values in summer and winter.