Precancerous conditions and epithelial dysplasia in the stomach.
TLDR
The criteria for grading Dysplasia in gastric epithelium into mild, moderate, and severe grades are given, and attention is drawn to the problems of differentiating inflammatory or regenerative change from mild dysplasia and intramucosal carcinoma from severe dyspl Asia.Abstract:
A distinction can be made between a precancerous condition and a precancerous lesion. The former is a clinical state associated with a significantly increased risk of cancer, whereas a precancerous lesion is a histopathological abnormality in which cancer is more likely to occur than in its apparently normal counterpart. Up to the present time atrophic gastritis, gastric ulcer, pernicious anaemia, gastric stumps, gastric polyps, and Menetrier's disease have all been considered as precancerous conditions and lesions of the stomach. Of these, only atrophic gastritis, pernicious anaemia, gastric stumps, and certain types of gastric polyp can now be regarded as having any really significant malignant potential. The precancerous lesion common to these is epithelial dysplasia which can occur in ordinary (foveolar) gastric epithelium as well as in intestinal metaplasia. The criteria for grading dysplasia in gastric epithelium into mild, moderate, and severe grades are given, and attention is drawn to the problems of differentiating inflammatory or regenerative change from mild dysplasia and intramucosal carcinoma from severe dysplasia. The clinical and epidemiological implications of gastric dysplasia are discussed with suggestions for further research.read more
Citations
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Barrett's esophagus: development of dysplasia and adenocarcinoma.
TL;DR: The results of this study support the need for a long-term clinical, endoscopic, and histologic follow-up program in patients with Barrett's esophagus with an incidence of carcinoma of 1 in 52 patient-years, a 125-fold increase compared with the general Dutch population.
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Gastroesophageal Reflux Disease
TL;DR: A 53-year-old man, who is otherwise healthy and has a 20-year history of occasional heartburn, reports having had worsening heartburn for the past 12 months, with daily symptoms that disturb his sleep as mentioned in this paper.
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5‐Aminolevulinic Acid‐Based Photodynamic Therapy: Principles and Experimental Research
TL;DR: Because PpIX is an efficient photosensitizer, ALA has been introduced as a drug for clinical photodynamic therapy (PDT) of cancer (8,9).
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Gastric dysplasia: the Padova international classification.
Massimo Rugge,Pelayo Correa,Michael F. Dixon,Takanori Hattori,Gioacchino Leandro,Klaus J. Lewin,Robert H. Riddell,Pentii Sipponen,Hidenobu Watanabe +8 more
TL;DR: The international Padova classification of the gastric precancerous lesions is submitted to the attention of the international scientific community, which is invited to test and to improve on it.
Journal ArticleDOI
Pathology of colorectal adenomas: a colonoscopic survey.
F Konishi,B C Morson +1 more
TL;DR: The size, histological type, and grade of dysplasia of a large series of colorectal adenomas removed by colonoscopic polypectomy were matched against other variables such as anatomical site, age, sex, and number ofAdenomas per patients to show the possible significance of severe Dysplasia as a selective marker for increased coloreCTal cancer risk.
References
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Journal ArticleDOI
Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa.
TL;DR: ImagesFigs.
Journal ArticleDOI
Carcinoma and intestinal metaplasia of the stomach in Colombian migrants.
Journal ArticleDOI
Gastric cancer in Colombia. III. Natural history of precursor lesions.
Pelayo Correa,Carlos Cuello,Edgar Duque,Luis Carlos Burbano,F. T. García,Oscar Bolanos,Charles C. Brown,William Haenszel +7 more
TL;DR: Differences corresponding to the geographic variation in stomach cancer risk were found: in the high-risk areas of Nariño, around 75% of the population developed some type of gastritis by 45 years of age, whereas in the low- and intermediate-risk population of Cartagena and Cali, the proportion of such lesions did not exceed 50% at age 45 or thereafter.
Journal ArticleDOI
Stomach cancer following gastric surgery for benign conditions
Helge Stalsberg,Sigbjörn Taksdal +1 more
TL;DR: Among 630 cases of gastric cancer submitted to necropsy the frequency of previous gastric surgery for benign conditions was lower than among matched controls for patients operated on less than 15 years before death, but was increased to about six times the frequency among controls for Patients operated on 25 years and more before death.
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