Journal ArticleDOI
Predicting Psychosis: Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk
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This article is published in Yearbook of Psychiatry and Applied Mental Health.The article was published on 2013-01-01. It has received 560 citations till now.read more
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Applications of blood-based protein biomarker strategies in the study of psychiatric disorders.
Man K. Chan,Michael G. Gottschalk,Frieder Haenisch,Jakub Tomasik,Jakub Tomasik,Tillmann Ruland,Tillmann Ruland,Hassan Rahmoune,Paul C. Guest,Sabine Bahn,Sabine Bahn +10 more
TL;DR: It is anticipated that the implementation of validated biomarker tests will not only improve the diagnosis and more effective treatment of psychiatric patients, but also improve prognosis and disease outcome.
Journal ArticleDOI
Neurocognitive and Clinical Predictors of Long-Term Outcome in Adolescents at Ultra-High Risk for Psychosis: A 6-Year Follow-Up
Tim Ziermans,Sanne de Wit,Patricia F. Schothorst,Mirjam Sprong,Herman van Engeland,René S. Kahn,Sarah Durston +6 more
TL;DR: The severity of attenuated positive symptoms was the only significant predictor of a transition to psychosis and disorganized symptoms were highly predictive of functional outcome.
Journal ArticleDOI
Prediction of transition to psychosis in patients with a clinical high risk for psychosis: a systematic review of methodology and reporting.
TL;DR: Most published models are probably overfitted and their reported predictive accuracy is likely to be overoptimistic, according to a systematic review of studies developing or validating multivariable clinical prediction models.
Journal ArticleDOI
Evidence-based early interventions for individuals at clinical high risk for psychosis: a review of treatment components.
Elizabeth Thompson,Zachary B. Millman,Nana Okuzawa,Vijay A. Mittal,Jordan E. DeVylder,Travis Skadberg,Robert W. Buchanan,Gloria Reeves,Jason Schiffman +8 more
TL;DR: This article proposes an empirically based, flexible, and comprehensive modularized approach to early intervention that meets the varying needs of individuals experiencing CHR-related distress and dysfunction, many of whom may be on a trajectory toward psychosis.
Journal ArticleDOI
Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis
Danielle A. Schlosser,Timothy R. Campellone,Timothy R. Campellone,Bruno Biagianti,Kevin L. Delucchi,David E. Gard,Daniel Fulford,Barbara K. Stuart,Melissa Fisher,Melissa Fisher,Rachel Loewy,Sophia Vinogradov,Sophia Vinogradov +12 more
TL;DR: It is suggested that experiences of motivational impairment are more important in determining social functioning, relative to affective flattening and alogia, in CHR individuals, thereby informing the development of more precise therapeutic targets.
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Journal ArticleDOI
Predicting Psychosis: Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk
Paolo Fusar-Poli,Ilaria Bonoldi,Alison R. Yung,Stefan Borgwardt,Matthew J. Kempton,Lucia Valmaggia,Francesco Barale,Edgardo Caverzasi,Philip McGuire +8 more
TL;DR: The state of clinical high risk is associated with a very high risk of developing psychosis within the first 3 years of clinical presentation, and the risk progressively increases across this period.
Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk
Paolo Fusar-Poli,Ilaria Bonoldi,Alison R. Yung,Stefan Borgwardt,Matthew J. Kempton,Lucia Valmaggia,Francesco Barale,Edgardo Caverzasi,Philip McGuire +8 more
TL;DR: In this article, the authors examined the literature to date reporting the transition risk to psychosis in subjects at clinical high risk and found that there was a consistent transition risk, independent of the psychometric instruments used, of 18% after 6 months of follow-up, 22% after 1 year, 29% after 2 years and 36% after 3 years.