Journal ArticleDOI
Prediction of polymer dissolution in swellable controlled-release systems☆
Ping I. Lee,Nicholas A. Peppas +1 more
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TLDR
In this paper, a mathematical model was developed to describe the dissolution process of a glassy polymer by a thermodynamically compatible penetrant, which was verified by available experimental data from the fields of controlled release and micro-lithography.About:
This article is published in Journal of Controlled Release.The article was published on 1987-12-01. It has received 188 citations till now. The article focuses on the topics: Dissolution & Penetrant (mechanical, electrical, or structural).read more
Citations
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A review of polymer dissolution
TL;DR: In this paper, a general overview of several aspects of the dissolution of amorphous polymers is provided, including experimentally observed dissolution phenomena and mechanisms reported to this date, solubility behavior of polymers and their solvents, models used to interpret and understand polymer dissolution, and techniques used to characterize the dissolution process.
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Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems
TL;DR: This article aims to provide a comprehensive review of existing mathematical models and simulations of drug release from polymeric microspheres and of drug transport in adjacent tissues and to evaluate the application of existing models to nanoscale drug delivery systems specifically for hydrophobic and hydrophilic molecules.
Journal ArticleDOI
Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance.
TL;DR: Gel-layer behaviour, front movement and release are described to show the dependence of the release kinetics on the swelling behaviour of the system and in vivo behaviour of matrix systems.
Journal ArticleDOI
Pharmaceutical significance of cellulose: A review
TL;DR: In this article, the current knowledge on the structure and chemistry of cellulose, and in the development of innova- tive cellulose esters and ethers for pharmaceuticals is assembled.
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Swelling-controlled release in hydrogel matrices for oral route
TL;DR: The release mechanisms, modelling and mathematical analysis of release data are described, in order to show the dependence of the release kinetics on the movement of the fronts delimiting the undissolved core and the partially extracted region.
References
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Book
Viscoelastic properties of polymers
TL;DR: In this article, the authors describe the nature of Viscoelastic behavior of polymeric systems and approximate relations among the linear Viscoels and approximate interrelations among the Viscelastic Functions.
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Mechanisms of solute release from porous hydrophilic polymers
TL;DR: In this article, the role of dynamic swelling and the dissolution of the polymer matrix on the release mechanism was discussed, as well as the effect of the tracer/excipient ratio on the poly(vinyl alcohol) release profile.
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Kinetics of drug release from hydrogel matrices
TL;DR: The kinetics of drug release from hydrogel matrices will be examined both experimentally and theoretically and special emphasis will be placed on the effect of local drug concentration on the swelling behavior ofhydrogel drug carriers.
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Diffusional release of a solute from a polymeric matrix — approximate analytical solutions
TL;DR: In this article, a refined integral method has been successfully applied to moving boundary problems encountered in the diffusional release of a solute from a polymeric matrix, and the release kinetics has been analyzed for both erodible and non-erodible matrices with perfect sink and constant, finite external volume conditions.
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Solute and penetrant diffusion in swellable polymers. II. Verification of theoretical models
TL;DR: In this article, a mathematical model for describing diffusion of a penetrant and a solute in a swellable polymer slab was applied to the case of a hydrophilic polymer loaded with a soluble drug in which the penetrant (water) is sorbed and solute (drug) is desorbed.