Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review
Alexander Weymann,Anton Sabashnikov,Sadeq Ali-Hasan-Al-Saegh,Aron-Frederik Popov,Seyed Jalil Mirhosseini,William L. Baker,Mohammad Reza Lotfaliani,Tong Liu,Hamidreza Dehghan,Senol Yavuz,Michel Pompeu Barros de Oliveira Sá,Jae-Sik Jang,Mohamed Zeriouh,Lei Meng,Fabrizio D'Ascenzo,Abhishek Deshmukh,Guiseppe Biondi-Zoccai,Pascal M. Dohmen,Hugh Calkins +18 more
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TLDR
The levels of coagulation, fibrinolytic, and endothelial markers have been reported to be significantly higher in AF patients than in SR patients and the role of prothrombotic markers in AF remains inconclusive.Abstract:
BACKGROUND The pathophysiological mechanism associated with the higher prothrombotic tendency in atrial fibrillation (AF) is complex and multifactorial. However, the role of prothrombotic markers in AF remains inconclusive. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating the association of coagulation activation, fibrinolytic, and endothelial function with occurrence of AF and clinical adverse events. A comprehensive subgroup analysis and meta-regression was performed to explore potential sources of heterogeneity. RESULTS A literature search of major databases retrieved 1703 studies. After screening, a total of 71 studies were identified. Pooled analysis showed the association of coagulation markers (D-dimer (weighted mean difference (WMD) =197.67 and p<0.001), fibrinogen (WMD=0.43 and p<0.001), prothrombin fragment 1-2 (WMD=0.53 and p<0.001), antithrombin III (WMD=23.90 and p=0.004), thrombin-antithrombin (WMD=5.47 and p=0.004)); fibrinolytic markers (tissue-type plasminogen activator (t-PA) (WMD=2.13 and p<0.001), plasminogen activator inhibitor (WMD=11.44 and p<0.001), fibrinopeptide-A (WMD=4.13 and p=0.01)); and endothelial markers (von Willebrand factor (WMD=27.01 and p<0.001) and soluble thrombomodulin (WMD=3.92 and p<0.001)) with AF. CONCLUSIONS The levels of coagulation, fibrinolytic, and endothelial markers have been reported to be significantly higher in AF patients than in SR patients.read more
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Journal ArticleDOI
Inflammation and atrial fibrillation: A comprehensive review.
Panagiotis Korantzopoulos,Konstantinos P. Letsas,Gary Tse,Nikolaos Fragakis,Christos A. Goudis,Tong Liu +5 more
TL;DR: An updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers.
Journal ArticleDOI
Evidence for Inflammation as a Driver of Atrial Fibrillation.
Xiaoxu Zhou,Samuel C. Dudley +1 more
TL;DR: The roles of inflammation in the occurrence, development, and mechanisms of AF are reviewed and the therapeutic implications of the correlation of inflammation and AF are reviews.
Journal ArticleDOI
Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: a systematic review with meta-analysis.
Alexander Weymann,Sadeq Ali-Hasan-Al-Saegh,Aron Frederik Popov,Aron Frederik Popov,Aron Frederik Popov,Anton Sabashnikov,Seyed Jalil Mirhosseini,Tong Liu,Gary Tse,Mohammad Reza Lotfaliani,Azam Ghanei,Luca Testa,Fabrizio D'Ascenzo,Umberto Benedetto,Hamidreza Dehghan,Leonardo Roever,Michel Pompeu Barros de Oliveira Sá,William L. Baker,Senol Yavuz,M. Zeriouh,Ahmed Mashhour,Luis Nombela-Franco,Jae Sik Jang,Lei Meng,Mengqi Gong,Abhishek Deshmukh,Tullio Palmerini,Cecilia Linde,Krzysztof J. Filipiak,Giuseppe Biondi-Zoccai,Giuseppe Biondi-Zoccai,Hugh Calkins,Gregg W. Stone +32 more
TL;DR: Haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft, isolated valvular surgery, or a combination of these treatments may predict the risk of POAF before surgery.
Journal ArticleDOI
Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis
Alexander Weymann,Sadeq Ali-Hasan-Al-Saegh,Anton Sabashnikov,Aron Frederik Popov,Aron Frederik Popov,Seyed Jalil Mirhosseini,Tong Liu,Mohammad Reza Lotfaliani,Michel Pompeu Barros de Oliveira Sá,William L. Baker,Senol Yavuz,Mohamed Zeriouh,Jae-Sik Jang,Hamidreza Dehghan,Lei Meng,Luca Testa,Fabrizio D'Ascenzo,Umberto Benedetto,Gary Tse,Luis Nombela-Franco,Pascal M. Dohmen,Pascal M. Dohmen,Abhishek Deshmukh,Cecilia Linde,Giuseppe Biondi-Zoccai,Gregg W. Stone,Hugh Calkins +26 more
TL;DR: Hematological parameters have significant ability to predict occurrence and recurrence of AF, and it is recommended to add the CBC test to the diagnostic modalities of AF in clinical practice.
Journal ArticleDOI
Baseline and postoperative levels of C-reactive protein and interleukins as inflammatory predictors of atrial fibrillation following cardiac surgery: a systematic review and meta-analysis.
Alexander Weymann,Aron Frederik Popov,Anton Sabashnikov,Sadeq Ali-Hasan-Al-Saegh,Mikhail Ryazanov,Gary Tse,Seyed Jalil Mirhosseini,Tong Liu,Mohammad Reza Lotfaliani,Meghdad Sedaghat,William L. Baker,Azam Ghanei,Senol Yavuz,Mohamed Zeriouh,Payman Izadpanah,Hamidreza Dehghan,Luca Testa,Maryam Nikfard,Michel Pompeu Barros de Oliveira Sá,Ahmed Mashhour,Luis Nombela-Franco,Mohammad Rezaeisadrabadi,Fabrizio D'Ascenzo,Konstantin Zhigalov,Umberto Benedetto,Soroosh Aminolsharieh Najafi,Marcin Szczechowicz,Leonardo Roever,Lei Meng,Mengqi Gong,Abhishek Deshmukh,Tullio Palmerini,Cecilia Linde,Krzysztof J. Filipiak,Gregg W. Stone,Giuseppe Biondi-Zoccai,Giuseppe Biondi-Zoccai,Hugh Calkins +37 more
TL;DR: Perioperative inflammation is proposed to be involved in the pathogenesis of POAF, and perioperative assessment of CRP, IL-6,IL-8, and IL-10 can help clinicians in terms of predicting and monitoring for POAF.
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TL;DR: No difference in hemostatic function was seen between the nonvalvular atrial fibrillation patients with and without a previous ischemic stroke, and alterations in he mostatic function may contribute to the increased risk of stroke in patients with nonvaluative atrialfibrillation.
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