Journal ArticleDOI
Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons
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TLDR
Data confirm that PS is a positive allosteric modulator of the NMDA receptor and provide evidence that this neurosteroid does not interact with the polyamine modulatory site.About:
This article is published in Brain Research.The article was published on 1995-01-16. It has received 54 citations till now. The article focuses on the topics: Dizocilpine & Pregnenolone sulfate.read more
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Journal ArticleDOI
Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators
TL;DR: This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.
Journal ArticleDOI
Steroid sulfatase: molecular biology, regulation, and inhibition.
TL;DR: The development of potent STS inhibitors will allow investigation of the role of this enzyme in physiological and pathological processes, and one such inhibitor, 667 COUMATE, has entered a phase I trial in postmenopausal women with breast cancer.
Book ChapterDOI
Neurosteroids: Endogenous role in the human brain and therapeutic potentials
TL;DR: Synthetic neurosteroids that exhibit better bioavailability and efficacy and drugs that enhance neurosteroid synthesis have therapeutic potential in anxiety, epilepsy, and other brain disorders.
Journal ArticleDOI
Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development
TL;DR: Evidence of mechanisms by which DHEA and DHEAS exert biological actions is provided, show that they have specific functions other than as sex steroid precursors, mediate their effects via non-classic steroid hormone receptors, and suggest that their developmentally regulated synthesis in vivo may play crucial and different roles in organizing the neocortex.
Journal ArticleDOI
Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism
TL;DR: The results demonstrate that the anti-amnesic effect of sigma 1 receptor agonists may be of therapeutic relevance in pathological states affecting the cholinergic and/or glutamatergic systems, such as in pathological aging.
References
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Journal ArticleDOI
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
Journal Article
Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.
TL;DR: Pregnenolone sulfate specifically enhances NMDA-gated currents in spinal cord neurons, while inhibiting receptors for the inhibitory amino acids glycine and gamma-aminobutyric acid, as well as non-NMDA glutamate receptors, consistent with the hypothesis that neurosteroids such as pregnenol one sulfate are involved in regulating the balance between excitation and inhibition in the central nervous system.
Journal ArticleDOI
Pregnenolone and its sulfate ester in the rat brain
C. Corpéchot,Monique Synguelakis,Saliha Talha,Magnus Axelson,Jan Sjövall,Reijo Vihko,Etienne-Emile Baulieu,Paul Robel +7 more
TL;DR: Brain P and PS levels did not seem to depend on steroidogenic gland secretion: no meaningful difference occurred in brain 15 days after adrenalectomy plus orchiectomy, compared with sham-operated controls and it is proposed that P andPS formation or accumulation in the rat brain depend on in situ mechanisms unrelated to the peripheral endocrine gland system.
Journal ArticleDOI
Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?
TL;DR: The interaction of the 'neurosteroid', pregnenolone-sulfate (PS), with the GABA/benzodiazepine/chloride ionophore receptor complex was investigated in rat brain subcellular preparations, suggesting the regulation of GABAergic neurotransmission by various neurosteroids may be an important mechanism for controlling neuronal excitability.
Journal ArticleDOI
Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.
TL;DR: The active cholesterol side-chain cleavage mechanism, recently suggested immunohistochemically and already observed in cultures of C6 glioma cells, reinforces the concept of "neurosteroids" applied to delta 5-3 beta-hydroxysteroids previously isolated from brain.