Journal ArticleDOI
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats
TLDR
Adult offsprings of rats treated with daily injection of chlordiazepoxide during pregnancy showed a significant decrease in benzodiazepine receptors in the cortex and the cerebellum without apparent changes in receptor affinity, and a reduced susceptibility to metrazol-induced epileptogenesis paralleled this change.About:
This article is published in Life Sciences.The article was published on 1985-05-06. It has received 24 citations till now. The article focuses on the topics: Chlordiazepoxide & Epileptogenesis.read more
Citations
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Book ChapterDOI
Prenatal adverse effects of nicotine on the developing brain
TL;DR: This chapter discusses the prenatal adverse effects of nicotine on the developing brain with actions of nutrition, metabolism and endocrine systems of both fetal and maternal organisms, including the placenta.
Journal ArticleDOI
Short-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural development of mice.
TL;DR: The main effect of prenatal oxazepam was an impairment of active avoidance responding, while the treatment effects on overall discrimination performance were less marked and limited to the later stages of training.
Journal ArticleDOI
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
TL;DR: The results are interpreted to reflect a long-lasting alteration in the function of the GABA/benzodiazepine receptor complex by prenatal diazepam exposure that is manifest at the behavioral and neurochemical level in a pharmacologic specific manner.
Journal ArticleDOI
Regulation of central and peripheral benzodiazepine receptors in progesterone-treated rats
TL;DR: The up-regulatory effect of progesterone on cortical central BZ receptors and peripheral BZ binding sites may be involved in the neurobehavioral activities of progestersone.
Journal ArticleDOI
Long-lasting behavioral changes induced by pre- or neonatal exposure to diazepam in rats.
A. Nicosia,Laura Giardina,Francesco Di Leo,Marilena Medico,Carmen Mazzola,Andrea A Genazzani,Filippo Drago +6 more
TL;DR: In adulthood, female rats exposed in early neonatal life to diazepam again showed a resistance to pentylenetetrazol-induced convulsions as compared to male animals, which may be influenced by sex-dependent factors.
References
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Journal ArticleDOI
Resolution of two biochemically and pharmacologically distinct benzodiazepine receptors
TL;DR: It is proposed that two biochemically distinct BDZ receptors exist in brain which are responsible for the mediation of different pharmacological activities.
Journal ArticleDOI
Sex differences in dendritic patterns in hamster preoptic area.
TL;DR: Results suggest sex differences in the afferent inputs to neurons in the dorsomedial preoptic area which may be related to functional sexual dimorphism in physiology and behavior.
Journal ArticleDOI
The gonad-brain relationship: effects of female sex hormones on electroshock convulsions in the rat.
TL;DR: The effects of ovariectomy and ovarian hormones on brain excitability were investigated in rats by measuring: (a) minimal electroshock seizure threshold, and (b) maximal electro shock seizure pattern.
Journal ArticleDOI
Benzodiazepines: Clinical Pharmacology and Therapeutic Use
Related Papers (5)
The effect of prenatal exposure to diazepam on aspects of postnatal development and behavior in rats
Nina Gai,Veronika E. Grimm +1 more