Prenatal exposure to famine and the development of hyperglycemia and type 2 diabetes in adulthood across consecutive generations: a population-based cohort study of families in Suihua, China.
Jie Li,Simin Liu,Songtao Li,Rennan Feng,Lixin Na,Xia Chu,Xiaoyan Wu,Yucun Niu,Zongxiang Sun,Tianshu Han,Haoyuan Deng,Xing Meng,Huan Xu,Zhe Zhang,Qiannuo Qu,Qiao Zhang,Ying Li,Changhao Sun +17 more
TLDR
Prenatal exposure to famine remarkably increases hyperglycemia risk in 2 consecutive generations of Chinese adults independent of known T2D risk factors, which supports the notion that prenatal nutrition plays an important role in the development of type 2 diabetes across consecutive generationsof Chinese adults.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-01-01 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Famine & Prenatal nutrition.read more
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Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations
TL;DR: This Perspective focuses on epigenetic mechanisms in germ cells, including DNA methylation, histone modification, and non-coding RNAs, which collectively may provide a non-genetic molecular legacy of prior environmental exposures and influence transcriptional regulation, developmental trajectories, and adult disease risk in offspring.
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Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine.
TL;DR: The role of the Chinese Famine in the current epidemic of type 2 diabetes mellitus in China is discussed and lessons to be learned are highlighted.
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Genomics of Islet (Dys)function and Type 2 Diabetes.
TL;DR: This review discusses how genome-wide association studies (GWASs) and recent developments in islet (epi)genome and transcriptome profiling (particularly single cell analyses) are providing novel insights into the genetic, environmental, and cellular contributions toIslet (dys)function and T2DM pathogenesis.
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Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases.
Shouneng Peng,Maya A. Deyssenroth,Antonio Fabio Di Narzo,Luca Lambertini,Carmen J. Marsit,Jia Chen,Ke Hao +6 more
TL;DR: It is suggested that transcripts in placenta are under tight genetic control, and that placental gene networks may influence postnatal risk of multiple human diseases lending support for the Developmental Origins of Health and Disease.
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Genetic variants influence on the placenta regulatory landscape
Fabien Delahaye,Catherine Do,Yu Kong,Remi Ashkar,Martha Salas,Benjamin Tycko,Ronald J. Wapner,Francine Hughes +7 more
TL;DR: The regulatory landscape of the human placenta is investigated and analytical approaches to integrate different types of genomic data and address some potential limitations of current platforms are offered, providing strong evidence for genotype-driven modifications of transcription and DNA methylation in normal placentas.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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Effect of In Utero and Early-Life Conditions on Adult Health and Disease
TL;DR: Evidence from several disciplines is synthesized to support the contention that environmental factors acting during development should be accorded greater weight in models of disease causation.
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Persistent epigenetic differences associated with prenatal exposure to famine in humans
Bastiaan T. Heijmans,Elmar W. Tobi,Aryeh D. Stein,Hein Putter,Gerard J. Blauw,Ezra Susser,P. Eline Slagboom,L. H. Lumey +7 more
TL;DR: It is shown that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944–45 had, 6 decades later, less DNA methylation of the imprinted IGF2 gene compared with their unexposed, same-sex siblings.
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Prevalence and control of diabetes in Chinese adults.
Yu Xu,Limin Wang,Jiang He,Yufang Bi,Mian Li,Tiange Wang,Linhong Wang,Yong Jiang,Meng Dai,Jieli Lu,Min Xu,Yichong Li,Nan Hu,Jianhong Li,Shengquan Mi,Chung Shiuan Chen,Guangwei Li,Yiming Mu,Jiajun Zhao,Lingzhi Kong,Jia-Lun Chen,Shenghan Lai,Weiqing Wang,Wenhua Zhao,Guang Ning +24 more
TL;DR: The estimated prevalence of diabetes among a representative sample of Chinese adults was 11.6% and the prevalence of prediabetes was 50.1%, which indicates the importance of diabetes as a public health problem in China.
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Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution
Eva Jablonka,Gal Raz +1 more
TL;DR: The analysis of data shows that epigenetic inheritance is ubiquitous and suggests lines of research that go beyond present approaches to the subject, as well as pointing to the importance of recognizing and understanding epigenetics for practical and theoretical issues in biology.