Journal ArticleDOI
Prevalence of nodal involvement in rectal cancer after chemoradiotherapy
Hester E. Haak,Hester E. Haak,Geerard L. Beets,Geerard L. Beets,Koen C.M.J. Peeters,Patricia J. Nelemans,V. Valentini,Claus Rödel,Li Jen Kuo,Felipe A. Calvo,Julio Garcia-Aguilar,Rob Glynne-Jones,Salvatore Pucciarelli,Javier Suárez,George Theodoropoulos,S Biondo,S Biondo,Doenja M. J. Lambregts,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan,Monique Maas +20 more
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TLDR
In this article, the authors investigated the prevalence of nodal metastases (ypN+) status according to ypT category in patients with locally advanced rectal cancer treated with chemoradiotherapy and total mesorectal excision, and assessed the impact of ypN+ on disease recurrence and survival by pooled analysis of individual-patient data.Abstract:
BACKGROUND The purpose of this study was to investigate the prevalence of ypN+ status according to ypT category in patients with locally advanced rectal cancer treated with chemoradiotherapy and total mesorectal excision, and to assess the impact of ypN+ on disease recurrence and survival by pooled analysis of individual-patient data. METHODS Individual-patient data from 10 studies of chemoradiotherapy for rectal cancer were included. Pooled rates of ypN+ disease were calculated with 95 per cent confidence interval for each ypT category. Kaplan-Meier and Cox regression analyses were undertaken to assess influence of ypN status on 5-year disease-free survival (DFS) and overall survival (OS). RESULTS Data on 1898 patients were included in the study. Median follow-up was 50 (range 0-219) months. The pooled rate of ypN+ disease was 7 per cent for ypT0, 12 per cent for ypT1, 17 per cent for ypT2, 40 per cent for ypT3, and 46 per cent for ypT4 tumours. Patients with ypN+ disease had lower 5-year DFS and OS (46.2 and 63.4 per cent respectively) than patients with ypN0 tumours (74.5 and 83.2 per cent) (P < 0.001). Cox regression analyses showed ypN+ status to be an independent predictor of recurrence and death. CONCLUSION Risk of nodal metastases (ypN+) after chemoradiotherapy increases with advancing ypT category and needs to be considered if an organ-preserving strategy is contemplated.read more
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Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
TL;DR: In this paper , microsatellite instability (MSI) was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.
Journal ArticleDOI
Predictive value of proteomic markers for advanced rectal cancer with neoadjuvant chemoradiotherapy
Han-Yang Wang,Dengbo Ji,Huifang Tian,Zhaoya Gao,Can Song,Jinying Jia,Xinxin Cui,Lijun Zhang,Jing Shen,Jin Gu +9 more
TL;DR: In this paper , a 10-protein panel for nCRT response prediction and four potential biomarkers HEP2, GELS, S10A8 and APOA1 for prognosis of rectal cancer based on iTRAQ-based comparative proteomics screening and PRM-based targeted proteomic validation were identified and confirmed.
Journal ArticleDOI
Predictive value of proteomic markers for advanced rectal cancer with neoadjuvant chemoradiotherapy
Han-Yang Wang,Dengbo Ji,Huifang Tian,Zhaoya Gao,Can Song,Jinying Jia,Xinxin Cui,Lijun Zhang,Jing Shen,Jin Gu +9 more
TL;DR: In this paper , a 10-protein panel for nCRT response prediction and four potential biomarkers HEP2, GELS, S10A8 and APOA1 for prognosis of rectal cancer based on iTRAQ-based comparative proteomics screening and PRM-based targeted proteomic validation were identified and confirmed.
Journal ArticleDOI
Collagen score in the tumor microenvironment predicts the prognosis of rectal cancer patients after neoadjuvant chemoradiotherapy
TL;DR: The CSIM-CT was created based on 3 features: collagen area, number of collagen fibers and a Gabor textural feature as mentioned in this paper . But the CSIMCT was not associated with DFS and OS in the two cohorts.
Journal ArticleDOI
A nomogram prediction model for lymph node metastasis risk after neoadjuvant chemoradiotherapy in rectal cancer patients based on SEER database
TL;DR: In this article , a nomogram based on multivariate logistic regression was created using decision curve analyses to predict the likelihood of lymph node metastases in rectal cancer patients following neoadjuvant chemoradiotherapy.
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Metaprop: a Stata command to perform meta-analysis of binomial data
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