Journal ArticleDOI
Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis
Fernanda Weber Mello,Andressa Fernanda Paza Miguel,Kamile Leonardi Dutra,André Luís Porporatti,Saman Warnakulasuriya,Eliete Neves Silva Guerra,Elena Riet Correa Rivero +6 more
TLDR
The overall prevalence of OPMD worldwide was 4.47%, and males were more frequently affected by these disorders, and the prevalence differs between populations; therefore, further population-based studies may contribute to the better understanding of these differences.Abstract:
Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta-analysis was to answer the question: "What is the prevalence of oral potentially malignant disorders among adults?" Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis [OSMF], and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included. Of the 5513 studies, 22 met the inclusion criteria for qualitative and quantitative analyses. The risk of bias (RoB) of the selected studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Seven studies were classified as high risk, 12 as moderate risk, and 3 as low RoB. The meta-analysis showed that the prevalence of OPMD was 4.47% (95% CI = 2.43-7.08). The most prevalent OPMDs were OSMF (4.96%; 95% CI = 2.28-8.62) and leukoplakia (4.11%; 95% CI = 1.98-6.97). OPMDs were identified more commonly in males (59.99%; 95% CI = 41.27-77.30). Asian and South American/Caribbean populations had the highest prevalence rates of 10.54% (95% CI = 4.60-18.55) and 3.93% (95% CI = 2.43-5.77), respectively. The overall prevalence of OPMD worldwide was 4.47%, and males were more frequently affected by these disorders. The prevalence of OPMD differs between populations; therefore, further population-based studies may contribute to the better understanding of these differences.read more
Citations
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Journal ArticleDOI
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Saman Warnakulasuriya,Omar Kujan,José Manuel Aguirre-Urizar,Jose V. Bagan,Miguel Ángel González-Moles,Alexander Ross Kerr,Giovanni Lodi,Fernanda Weber Mello,Luís Monteiro,Graham R. Ogden,Philip Sloan,Newell W. Johnson,Newell W. Johnson +12 more
TL;DR: It is recommended the establishment of a global research consortium to further study the natural history of OPMDs based on the classification and nomenclature proposed here, and link them to evidence-based interventions, to facilitate the prevention and management of lip and oral cavity cancer.
Journal ArticleDOI
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta‐analysis of malignant transformation rate by subtype
Oreste Iocca,Thomas P. Sollecito,Faizan Alawi,Gregory S. Weinstein,Jason G. Newman,Armando De Virgilio,Pasquale Di Maio,Giuseppe Spriano,Simón Pardiñas López,Rabie M. Shanti +9 more
TL;DR: Potentially malignant disorders of the oral cavity (OPMD) are a heterogeneous group of lesions associated with a variable risk of malignant transformation (MT) to invasive cancer.
Journal ArticleDOI
Oral potentially malignant disorders: A comprehensive review on clinical aspects and management
TL;DR: Oral potentially malignant disorders (OPMDs) include a group of conditions that affect the oral mucosa with an increased risk of malignancy and up to a third of OPMDs may transform to squamous cell carcinomas.
Journal ArticleDOI
Malignant transformation of oral leukoplakia: systematic review and meta‐analysis of the last 5 years
TL;DR: In this paper, the authors performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords "oral leukoplakia", "oral cancer", ''oral carcinoma" and ''oral squamous cell carcinoma''.
Journal ArticleDOI
World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies.
Alessandro Villa,Alessandro Villa,Antonio Celentano,Ingrid Glurich,Wenche S. Borgnakke,Siri Beier Jensen,Douglas E. Peterson,Konstantina Delli,David Ojeda,Arjan Vissink,Camile S. Farah +10 more
TL;DR: This review identified insufficient longitudinal evidence to support validated prognostic biomarkers for oral leukoplakia and further studies are needed to identify molecular targets with the potential to mitigate risk of malignant transformation.
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