Showing papers in "Oral Oncology in 2006"

TL;DR: Current evidence implicates collagen-related genes in the susceptibility and pathogenesis of OSF and the individual mechanisms operating at various stages of the disease-initial, intermediate and advanced need further study in order to propose appropriate therapeutic interventions.

TL;DR: The prognostic value of histopathological features related to the primary tumour and the cervical lymph nodes are described, and their relative merits are considered.

TL;DR: The long-term outcome of oral premalignant lesions, leukoplakia and erythroplakia, with or without surgical intervention was learned to relate the outcome to factors supposed to be significant for malignant development including clinical type, demarcation, size, site, presence of epithelial dysplasia, smoking and surgery.

TL;DR: The present study showed that more consensus scoring on either the degree of dysplasia, assessment of risk or the presence of each morphological characteristic by a panel should be encouraged, and the new binary grading system complemented the WHO Classification 2005 and may have merit in helping clinicians to make critical clinical decisions particularly for the cases of moderate Dysplasia.

TL;DR: An attempt has been made to collate the information available on mechanisms of action of 4NQO, studies carried out for the development of biomarkers and chemopreventives agents using 4NZO animal models, which suggest that similar histological as well as molecular changes are observed in the human system.

TL;DR: Reported response rates to combination chemotherapy are low and response duration generally short lived, and the response to molecular therapies is low also.

TL;DR: According to the findings, clinical stage, solid growth pattern and expression of p53 were the most important prognostic factors in patients with ACC.

TL;DR: Evidence is provided of a continuing increase in the burden of oral cancer across the UK, which remains higher in men than women, in older compared with younger groups, and in northern regions.

TL;DR: The elective neck treatment resulted in better regional control and the results of salvage treatment were poor, and the risk for occult cervical metastasis is high in patients with early tongue tumours and only carefully selected patients can be left without prophylactic neck treatment.

TL;DR: The rationale behind selectiveneck dissection, its application in the clinically negative but histologically node-positive neck and the extended application of selective neck dissection in patients with clinical evidence of nodal disease are discussed.

TL;DR: The present study shows for the first time mutations of HRPT2 gene in OF and suggests that OF may arise due to haploinsufficiency of the HR PT2 gene.

TL;DR: The epidemiology, aetiology, clinical features and microbiological aspects of oral candidosis in a cohort of cancer patients receiving specialist palliative care were determined, and Candida albicans was the predominant organism isolated from the oral swabs of patients with Oral candidosis.

TL;DR: It is demonstrated that B7-H1 is predominantly induced on oral SCC within the B7 family molecules, and a successful inhibition of tumor growth by blockade of the PD-1:B7- H1 pathway may implicate a new approach for immunotherapy of oral S CC.

TL;DR: Results suggest that polymorphisms in functionally important repair genes, specifically, those that map onto the protein surface may alter protein function without significantly affecting its structure.

TL;DR: Analysis of surgical biopsies from oral squamous cell carcinoma indicated that weak or undetectable E-cadherin expression is an indicator of shorter disease-free period and shorter survival time.

TL;DR: The results suggest that Dark Royal Blue staining is the true positive outcome of a TB test and showed that DarkRoyal Blue-malignant and Dark RoyalBlue-benign lesions have a different histological pattern of uptake.

TL;DR: The result showed a relatively better tumor control and survivals in BSCC with radical surgery with or without neck dissection, and it is suggested that elective ND is indicated only when tumor depth > or =6 mm.

TL;DR: C-KIT protein does not appear to be an exclusively specific marker for benign or malignant salivary gland neoplasms, but may be useful in differential diagnosis of adenoid cystic carcinoma from polymorphous low grade adenocarcinoma.

TL;DR: Laryngeal small cell neuroendocrine carcinomas are chiefly treated by way of radiation and chemotherapy; the role of adjuvant therapy in the treatment of atypical carcinoid tumours remains to be established.

TL;DR: The new classification of head and neck tumours was published in July 2005 and a clarification of the metastasising ameloblastoma, which was inaccurately described in the 1992 classification, has now been achieved.

TL;DR: Fifteen cases of head and neck amyloid, excluding the brain, with clinical follow-up were identified in the Surgical Pathology files from 1985 to 2005 at Emory University Hospital, and the histopathology, histochemistry, and patient follow- up were reviewed.

TL;DR: The need for tailored information provision and the impact on longitudinal outcomes of satisfying patient’s needs for information prior to treatment is highlighted.

TL;DR: Patients who underwent salvage surgery with or without postoperative radiotherapy had significantly improved salvage and total survival times compared with patients who received chemotherapy and/or radiation therapy for their recurrence.

TL;DR: The several rodent models used for in vivo evaluation for oral cancer employ chemical, transplantation and genetic (knockout and transgenic) induction methods, together with their advantages and disadvantages, that may improve the early detection and treatment of oral cancer.

TL;DR: Optical spectroscopy has not only been shown to have a role in the detection of dysplasia and malignancy but also in performing guided biopsies, monitoring of haemoglobin tissue perfusion in free-flaps and therapeutic drug levels during chemo- and photodynamic therapy.

TL;DR: The study showed that apparently a diagnosis of OLP or OLL makes no difference for the patient regarding malignant transformation, although in OLP p53 showed a higher index of expression, probably related to the intensity of inflammatory infiltrate.

TL;DR: This observational cohort study prospectively compared the yield of whole body (18)FDG-PET and chest CT to detect distant metastases and synchronous primary tumours in patients with HNSCC to identify unknown malignancy in 6% of the patients.

TL;DR: Fifty healthy volunteers were studied to assess the potential applications of oral brush sampling using liquid-based cytology as a screening tool for oral cancer and precancer, and cases showed good quality positive FHIT immunoreactivity staining.

TL;DR: The results suggest that hypoxia activates the HGF/c-Met system via HIF-1alpha in human salivary gland cancers and might be involved in their metastasis.