Journal ArticleDOI
Prevention and management of glucocorticoid-induced side effects: A comprehensive review: A review of glucocorticoid pharmacology and bone health
TLDR
A series of tables and algorithms based on a review of relevant data are created to guide counseling, prophylaxis, and management of 11 glucocorticoid side effects.Abstract:
Systemic glucocorticoids are an essential therapy for a range of conditions, but their multiple side effects can produce significant morbidity for patients. The objective of this review is to discuss these side effects while addressing 3 questions: 1) What dose and duration of glucocorticoid therapy should prompt concern for individual side effects?; 2) How should clinicians counsel patients about these complications?; and 3) How can these problems be prevented or managed? To accomplish these objectives, we have created a series of tables and algorithms based on a review of relevant data to guide counseling, prophylaxis, and management of 11 glucocorticoid side effects. The first article in this 4-part continuing medical education series begins with a review of glucocorticoid pharmacology followed by a discussion of bone health (ie, osteoporosis and osteonecrosis).read more
Citations
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Journal ArticleDOI
American Society of Hematology 2019 guidelines for immune thrombocytopenia
Cindy Neunert,Deirdra R. Terrell,Donald M. Arnold,George R. Buchanan,Douglas B. Cines,Nichola Cooper,Adam Cuker,Jenny M. Despotovic,James N. George,Rachael F. Grace,Thomas Kühne,David J. Kuter,Wendy Lim,Keith R. McCrae,Barbara Pruitt,Hayley Shimanek,Sara K. Vesely +16 more
TL;DR: There was a lack of evidence to support strong recommendations for various management approaches, and a large focus was placed on shared decision-making, especially with regard to second-line therapy.
Journal ArticleDOI
Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment
TL;DR: Examination of fracture risk, using tools such as FRAX, is recommended in all patients treated with glucocorticoids, preferably around the time of treatment initiation, and treatment options are discussed.
Book ChapterDOI
Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair.
TL;DR: The functions of MMPs and their inhibitors in bone cells, during bone remodeling, pathological bone resorption (osteoporosis and bone metastasis), bone repair/regeneration, and emergent roles in bone bioengineering are discussed.
Journal ArticleDOI
Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement.
Aaron M. Drucker,Aaron M. Drucker,Aaron M. Drucker,Kilian Eyerich,M S de Bruin-Weller,Jacob P. Thyssen,Ph.I. Spuls,Alan D. Irvine,Giampiero Girolomoni,Sandipan Dhar,Carsten Flohr,Dedee F. Murrell,Amy S. Paller,Emma Guttman-Yassky +13 more
TL;DR: Guidelines discourage the use of systemic corticosteroids for atopic dermatitis (AD), but their use remains widespread.
Journal ArticleDOI
Autoimmune bullous skin diseases, pemphigus and pemphigoid.
TL;DR: Intensive investigation over the last 3 decades has identified their target antigens and developed serological diagnostic tools as well as mouse models to help understand their pathophysiology, and several new therapeutic approaches have become available, and more effective and less toxic targeted approaches are under development.
References
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Journal ArticleDOI
2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Neil J. Stone,Jennifer G. Robinson,Alice H. Lichtenstein,C. Noel Bairey Merz,Conrad B. Blum,Robert H. Eckel,Anne C. Goldberg,David Lee Gordon,Daniel Levy,Donald M. Lloyd-Jones,Patrick E. McBride,J. Sanford Schwartz,Susan T. Shero,Sidney C. Smith,Karol E. Watson,Peter W.F. Wilson +15 more
TL;DR: Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S2 The goals of the …
Journal ArticleDOI
American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.
Salvatore L. Ruggiero,Thomas B. Dodson,John Fantasia,Reginald Goodday,Tara Aghaloo,Bhoomi Mehrotra,Felice O'Ryan +6 more
TL;DR: The American Association of Oral and Maxillofacial Surgeons (AAOMS) developed guidelines for medication-related osteonecrosis of the jaw (MRONJ) in 2007 and 2009 as mentioned in this paper.
Journal ArticleDOI
Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research
Elizabeth Shane,David B. Burr,Peter R. Ebeling,Bo Abrahamsen,Robert A. Adler,Thomas D. Brown,Angela M. Cheung,Felicia Cosman,Jeffrey R. Curtis,Richard M. Dell,David W. Dempster,Thomas A. Einhorn,Harry K. Genant,Piet Geusens,Klaus Klaushofer,Kenneth J. Koval,Joseph M. Lane,Fergus McKiernan,Ross E. McKinney,Alvin Choong Meng Ng,Jeri W. Nieves,Regis J. O'Keefe,Socrates E. Papapoulos,Howe Tet Sen,Marjolein C. H. van der Meulen,Robert S. Weinstein,Michael P. Whyte +26 more
TL;DR: This newer evidence suggests that AFFs are stress or insufficiency fractures, and studies with radiographic review consistently report significant associations between A FFs and BP use, although the strength and magnitude of effect vary.
Journal Article
General recommendations on immunization; recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: This revision of the General Recommendations on Immunization updates the 1989 statement and changes in the immunization schedule for infants and children include recommendations that the third dose of oral polio vaccine be administered routinely at 6 months of age rather than at age 15 months.
Journal ArticleDOI
Bisphosphonate-associated osteonecrosis of the jaw: Report of a Task Force of the American Society for Bone and Mineral Research
Sundeep Khosla,David B. Burr,Jane A. Cauley,David W. Dempster,Peter R. Ebeling,Dieter Felsenberg,Robert F. Gagel,Vincente Gilsanz,Theresa A. Guise,Sreenivas Koka,Laurie K. McCauley,Joan McGowan,Marc D. McKee,Suresh Mohla,David G. Pendrys,Lawrence G. Raisz,Salvatore L. Ruggiero,David Shafer,Lillian Shum,Stuart L. Silverman,Catherine Van Poznak,Nelson B. Watts,Sook-Bin Woo,Elizabeth Shane +23 more
TL;DR: This report summarizes the findings and recommendations of the task force to address key questions related to case definition, epidemiology, risk factors, diagnostic imaging, clinical management, and future areas for research related to the disorder.
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2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Lenore Buckley,Gordon Guyatt,Howard A Fink,Michael Cannon,Jennifer M. Grossman,Karen E. Hansen,Mary Beth Humphrey,Nancy E Lane,Marina Magrey,Marc Miller,Lake Morrison,Madhumathi Rao,Angela Byun Robinson,Sumona Saha,Susan Wolver,Raveendhara R. Bannuru,Elizaveta E. Vaysbrot,Mikala C. Osani,Marat Turgunbaev,Amy S. Miller,Timothy E. McAlindon +20 more