Journal ArticleDOI
Principles and recent developments in chelation treatment of metal intoxication.
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This article is published in Chemical Reviews.The article was published on 1999-09-08. It has received 330 citations till now.read more
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Book ChapterDOI
Diagnosis and Treatment of Metal Poisoning: General Aspects
TL;DR: A detailed history is required where poisoning may occur in the domestic environment, particularly when poisoning results from the long-term absorption of cumulative metals as mentioned in this paper, where the exposure pattern in terms of time, concentration, and route of exposure is a determinant of the clinical effect.
Journal ArticleDOI
Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex.
Ladislav Habala,Ladislav Habala,Caroline Bartel,Gerald Giester,Michael A. Jakupec,Bernhard K. Keppler,Annette Rompel +6 more
TL;DR: The cytotoxicity of the vanadium(IV) complex was tested in vitro against three cancer cell lines, and cytotoxic potency in the multidrug-resistant non-small cell lung cancer cell line A549 was at least as high as in the broadly chemosensitive ovarian teratocarcinoma cell line CH1(PA-1).
Book ChapterDOI
Chelating Agents as Therapeutic Compounds—Basic Principles
TL;DR: While principles of chelation were briefly outlined in chapter: General Chemistry of Metal Toxicity and Basis for Metal Complexation, the basic requisites of chelating agents to be used in the clinical treatment of metal intoxication are discussed in more detail in the present chapter.
References
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Journal ArticleDOI
Hard and soft acids and bases
TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
Journal ArticleDOI
The long-term effects of exposure to low doses of lead in childhood. An 11-year follow-up report.
TL;DR: Exposure to lead in childhood is associated with deficits in central nervous system functioning that persist into young adulthood, and lead levels were inversely related to self-reports of minor delinquent activity.
Journal ArticleDOI
Drugs five years later. Cisplatin.
TL;DR: Although early trials showed marked gastrointestinal and renal toxicities, treatment-related morbidity has been significantly alleviated with modern antiemetic therapy and adequate pretreatment hydration.
Journal ArticleDOI
Penicillamine, a new oral therapy for Wilson's disease
TL;DR: A new form of oral treatment with dimethyl cysteine (penicillamine) is described, given in doses varying from 0.5 to 1.5 gm.
Journal ArticleDOI
Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action?
TL;DR: Desferrioxamine (deferoxamine) is an inhibitor of iron-dependent free radical reactions that has been used to investigate the role of such reactions in several animal model systems for human disease as mentioned in this paper.
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