Journal ArticleDOI
Progesterone-evoked increases in sperm [Ca2+]i correlate with the egg penetrating ability of sperm from fertile but not infertile men*
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TLDR
Progesterone-evoked increases in [Ca 2+ ]i in motile capacitated spermatozoa cannot be used to discriminate between dysfunctional spermutozoa and those capable of penetrating eggs.About:
This article is published in Fertility and Sterility.The article was published on 1994-06-01. It has received 36 citations till now. The article focuses on the topics: Sperm & Acrosome reaction.read more
Citations
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Journal ArticleDOI
Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa
Hannah Williams,Hannah Williams,Steven A. Mansell,Steven A. Mansell,Wardah Abdullah Alasmari,Sean G. Brown,Stuart M. Wilson,Stuart M. Wilson,Keith A. Sutton,Melissa R. Miller,Polina V. Lishko,Christopher L.R. Barratt,Christopher L.R. Barratt,SJ Publicover,Sarah Martins da Silva,Sarah Martins da Silva +15 more
TL;DR: It cannot be concluded that impaired CatSper function alone causes infertility or thatCatSper blockade is a potential safe target for contraception.
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Relationship Between Standard Semen Parameters, Calcium, Cholesterol Contents, and Mitochondrial Activity in Ejaculated Spermatozoa From Fertile and Infertile Males
Marcos Meseguer,Nicolás Garrido,José Antonio Martínez-Conejero,Carlos Simón,Antonio Pellicer,José Remohí +5 more
TL;DR: Intracellular concentrations of Ca2+ and the proportion of CH in the sperm membrane are two important markers of the sperm quality due to its direct relationship with sperm morphology and fertility potential.
Journal ArticleDOI
Extragenomic actions of progesterone in human sperm and progesterone metabolites in human platelets.
TL;DR: It is found that progesterone metabolites, such as pregnanolone and pregnanediol, promote a rapid rise in [Ca2+]i and aggregation in human platelets, similar to that observed with thrombin, and it is proposed that human platelet possess cell surface receptors for steroids.
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Progesterone action in a murine Leydig tumor cell line (mLTC-1), possibly through a nonclassical receptor type.
Talal El-Hefnawy,Pulak R. Manna,Michaela Luconi,Elizabetta Baldi,J. Peter Slotte,Ilpo Huhtaniemi +5 more
TL;DR: To characterize further the putative novel R, mediating these P effects in the murine Leydig tumor cell line, mLTC-1, the binding of [3H]P to these cells revealed a high and low affinity component, and the binding displayed with specificity.
Journal ArticleDOI
Progesterone promotes the acrosome reaction in capacitated human spermatozoa as judged by flow cytometry and CD46 staining
TL;DR: The results indicate that progesterone does promote an acrosome reaction within capacitated spermatozoa, and this concept has been challenged.
References
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A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
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Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor
TL;DR: RU 486, a steroid with high affinity for the progesterone receptor, is the first available active antiprogesterone, and it has been used successfully as a medical alternative for early pregnancy interruption.
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Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.
TL;DR: The effects of these progestins to increase [Ca2+]i, by activating a receptor-operated calcium channel, is the first report of such an activity in sperm.
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Steroid induced exocytosis: the human sperm acrosome reaction.
TL;DR: It is argued that progesterone is present at the site of fertilization of placental mammals in concentrations sufficient for activity, and hence provides a mechanism of inducing the acrosome reaction, an exocytotic event, in vivo.
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Intracellular Calcium Accumulation and Responsiveness to Progesterone in Capacitating Human Spermatozoa
TL;DR: The progressive, parallel increase of [Ca2+]i and response to progesterone observed during in vitro capacitation of human spermatozoa might be physiologically relevant in vivo during capacitating of sperm in the female genital tract.