Projected cancer risks from computed tomographic scans performed in the United States in 2007.
Amy Berrington de Gonzalez,Mahadevappa Mahesh,Kwang Pyo Kim,Mythreyi Bhargavan,Mythreyi Bhargavan,Rebecca S. Lewis,Fred A. Mettler,Charles E. Land +7 more
TLDR
These detailed estimates highlight several areas of CT scan use that make large contributions to the total cancer risk, including several scan types and age groups with a high frequency of use or scans involving relatively high doses, in which risk-reduction efforts may be warranted.Abstract:
Methods: Risk models based on the National Research Council’s “Biological Effects of Ionizing Radiation” report and organ-specific radiation doses derived from a national survey were used to estimate age-specific cancer risks for each scan type. These models were combined with age- and sex-specific scan frequencies for the US in 2007 obtained from survey and insurance claims data. We estimated the mean number of radiationrelatedincidentcancerswith95%uncertaintylimits(UL) using Monte Carlo simulations. Results:Overall,weestimatedthatapproximately29000 (95% UL, 15000-45000) future cancers could be related to CT scans performed in the US in 2007. The largest contributions were from scans of the abdomen and pelvis (n=14 000) (95% UL, 6900-25 000), chest (n=4100) (95% UL, 1900-8100), and head (n=4000) (95% UL, 1100-8700), as well as from chest CT angiography (n=2700) (95% UL, 1300-5000). One-third of the projectedcancerswereduetoscansperformedattheages of 35 to 54 years compared with 15% due to scans performed at ages younger than 18 years, and 66% were in females.read more
Citations
More filters
Journal ArticleDOI
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study
Mark S. Pearce,J Salotti,Mark P. Little,Kieran McHugh,Choonsik Lee,Kwang Pyo Kim,Nicola Howe,Cécile M. Ronckers,Preetha Rajaraman,Alan W. Craft,Louise Parker,Amy Berrington de Gonzalez +11 more
TL;DR: Use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukaemia and doses ofabout 60 m Gy might triple therisk of brain cancer.
Journal ArticleDOI
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: executive summary: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons.
Stephan D. Fihn,Julius M. Gardin,Jonathan Abrams,Kathleen Berra,James C. Blankenship,Apostolos P. Dallas,Pamela S. Douglas,JoAnne M. Foody,Thomas C. Gerber,Alan L. Hinderliter,Spencer B. King,Paul Kligfield,Harlan M. Krumholz,Raymond Y. Kwong,Michael J. Lim,Jane A. Linderbaum,Michael J. Mack,Mark A. Munger,Richard L. Prager,Joseph F. Sabik,Leslee J. Shaw,Joanna D. Sikkema,Craig R. Smith,Sidney C. Smith,John A. Spertus,Sankey V. Williams +25 more
TL;DR: A Report of the American College of Cardiology Foundation/AmericanHeart Association Task Force on Practice Guidelines, and the AmericanCollege of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for CardiovascularAngiography and Interventions, and Society of ThorACic Surgeons
Journal ArticleDOI
Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians
John D. Mathews,Anna V. Forsythe,Zoe Brady,Martin W Butler,Stacy Goergen,Graham Byrnes,Graham G. Giles,Anthony Wallace,Philip R Anderson,Philip R Anderson,Tenniel Guiver,Paul McGale,Timothy M. Cain,James G. Dowty,Adrian Bickerstaffe,Sarah C. Darby +15 more
TL;DR: The increased incidence of cancer after CT scan exposure in this cohort was mostly due to irradiation, and future CT scans should be limited to situations where there is a definite clinical indication, with every scan optimised to provide a diagnostic CT image at the lowest possible radiation dose.
Journal ArticleDOI
The Use of Computed Tomography in Pediatrics and the Associated Radiation Exposure and Estimated Cancer Risk
Diana L. Miglioretti,Diana L. Miglioretti,Eric Johnson,Andrew E. Williams,Robert T. Greenlee,Sheila Weinmann,Leif I. Solberg,Heather Spencer Feigelson,Douglas W. Roblin,Michael J. Flynn,Nicholas Vanneman,Rebecca Smith-Bindman +11 more
TL;DR: The increased use of CT in pediatrics, combined with the wide variability in radiation doses, has resulted in many children receiving a high-dose examination, and dose-reduction strategies targeted to the highest quartile of doses could dramatically reduce the number of radiation-induced cancers.
Journal ArticleDOI
Worldwide increasing incidence of thyroid cancer: Update on epidemiology and risk factors
Gabriella Pellegriti,Francesco Frasca,Concetto Regalbuto,Sebastiano Squatrito,Riccardo Vigneri +4 more
TL;DR: The increased incidence of thyroid cancer is most likely due to a combination of an apparent increase due to more sensitive diagnostic procedures and of a true increase, a possible consequence of increased population exposure to radiation and to other still unrecognized carcinogens.
References
More filters
Journal ArticleDOI
Computed Tomography — An Increasing Source of Radiation Exposure
David J. Brenner,Eric J. Hall +1 more
TL;DR: The facts are summarized about CT scans, which involve much higher doses of radiation than plain films, and the implications for public health are summarized.
sources and effects of ionizing radiation
TL;DR: This annex is aimed at providing a sound basis for conclusions regarding the number of significant radiation accidents that have occurred, the corresponding levels of radiation exposures and numbers of deaths and injuries, and the general trends for various practices, in the context of the Committee's overall evaluations of the levels and effects of exposure to ionizing radiation.
Book
Health Risks from Exposure to Low Levels of Ionizing Radiation:: BEIR VII Phase 2
TL;DR: Health risks from exposure to low levels of ionizing radiation : BEIR VII Phase 2 , Health risks from Exposure to low Levels of Ionizing radiation: BEIR VIII Phase 2, شاپور اهواز.
Journal ArticleDOI
Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries.
TL;DR: The results indicate that in the UK about 0.6% of the cumulative risk of cancer to age 75 years could be attributable to diagnostic X-rays, equivalent to about 700 cases of cancer per year.
Related Papers (5)
Computed Tomography — An Increasing Source of Radiation Exposure
David J. Brenner,Eric J. Hall +1 more