J
James G. Dowty
Researcher at University of Melbourne
Publications - 102
Citations - 5731
James G. Dowty is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 28, co-authored 88 publications receiving 4839 citations. Previous affiliations of James G. Dowty include Centre national de la recherche scientifique.
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Journal ArticleDOI
Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians
John D. Mathews,Anna V. Forsythe,Zoe Brady,Martin W Butler,Stacy Goergen,Graham Byrnes,Graham G. Giles,Anthony Wallace,Philip R Anderson,Philip R Anderson,Tenniel Guiver,Paul McGale,Timothy M. Cain,James G. Dowty,Adrian Bickerstaffe,Sarah C. Darby +15 more
TL;DR: The increased incidence of cancer after CT scan exposure in this cohort was mostly due to irradiation, and future CT scans should be limited to situations where there is a definite clinical indication, with every scan optimised to provide a diagnostic CT image at the lowest possible radiation dose.
Journal ArticleDOI
The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations
Leigha Senter,Mark Clendenning,Kaisa Sotamaa,Heather Hampel,Jane Green,John D. Potter,Annika Lindblom,Kristina Lagerstedt,Stephen N. Thibodeau,Noralane M. Lindor,Joanne P. Young,Ingrid Winship,James G. Dowty,Darren M. White,John L. Hopper,Laura Baglietto,Mark A. Jenkins,Albert de la Chapelle +17 more
TL;DR: PMS2 mutations contribute significantly to Lynch syndrome, but the penetrance for monoallelic mutation carriers appears to be lower than that for the other mismatch repair genes.
Journal ArticleDOI
Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers
Laura Baglietto,Noralane M. Lindor,James G. Dowty,Darren M. White,Anja Wagner,Encarna B. Gomez Garcia,Annette H. J. T. Vriends,Annette H. J. T. Vriends,Nicola Cartwright,Rebecca A. Barnetson,Susan M. Farrington,Albert Tenesa,Heather Hampel,Daniel D. Buchanan,Sven Arnold,Joanne P. Young,Michael Walsh,Jeremy R. Jass,Finlay A. Macrae,Yoland Antill,Ingrid Winship,Ingrid Winship,Graham G. Giles,Jack Goldblatt,Susan Parry,Graeme Suthers,Graeme Suthers,Barbara A. Leggett,Malinda L. Butz,Melyssa Aronson,Jenny N. Poynter,John A. Baron,Loic Le Marchand,Robert W. Haile,Steve Gallinger,John L. Hopper,John D. Potter,Albert de la Chapelle,Hans F. A. Vasen,Malcolm G. Dunlop,Stephen N. Thibodeau,Mark A. Jenkins +41 more
TL;DR: Estimates of both absolute and relative cancer risks for MSH6 mutation carriers are obtained, which are precise and accurate.
Journal ArticleDOI
Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study.
Mark A. Jenkins,Shinichi Hayashi,Anne Marie O'Shea,Lawrence J. Burgart,Thomas C. Smyrk,David Shimizu,Paul Waring,Andrew Ruszkiewicz,Aaron Pollett,Mark Redston,Melissa A. Barker,John A. Baron,Graham Casey,James G. Dowty,Graham G. Giles,Paul J. Limburg,Polly A. Newcomb,Joanne P. Young,Michael Walsh,Stephen N. Thibodeau,Noralane M. Lindor,Loic LeMarchand,Steven Gallinger,Robert W. Haile,John D. Potter,John L. Hopper,Jeremy R. Jass +26 more
TL;DR: There is little value in testing for DNA mismatch repair loss in tumors, or for germline mismatch repair mutations, for colorectal cancers diagnosed in patients before age 60 years with an MSPath score <1 (approximately 50%).
Journal ArticleDOI
Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer
Aung Ko Win,Mark A. Jenkins,James G. Dowty,Antonis C. Antoniou,Andy C. H. Lee,Graham G. Giles,Graham G. Giles,Daniel D. Buchanan,Mark Clendenning,Christophe Rosty,Dennis J. Ahnen,Stephen N. Thibodeau,Graham Casey,Steven Gallinger,Loc Le Marchand,Robert W. Haile,John D. Potter,John D. Potter,John D. Potter,Yingye Zheng,Yingye Zheng,Noralane M. Lindor,Polly A. Newcomb,Polly A. Newcomb,John L. Hopper,Robert J. MacInnis,Robert J. MacInnis +26 more
TL;DR: Unidentified major genes might explain one third to one half of the missing heritability of colorectal cancer in unidentified major genes, which could aid gene discovery and development of better coloreCTal cancer risk prediction models.