Journal ArticleDOI
Properties of incomplete Sendai virions and subgenomic viral RNAs
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The evidence indicates that noninfectious virions containing incomplete genomes occur in Sendai virus replication.About:
This article is published in Virology.The article was published on 1970-12-01. It has received 92 citations till now. The article focuses on the topics: Sendai virus.read more
Citations
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Journal ArticleDOI
Rapid evolution of RNA genomes
John J. Holland,Katherine R. Spindler,Katherine R. Spindler,Frank M. Horodyski,Elizabeth A. Grabau,Stuart T. Nichol,Scott VandePol +6 more
TL;DR: RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication, and high rates of replication reflected in rates of RNA genome evolution which can be more than a millionfold greater than the rates of the DNA chromosome evolution of their hosts.
Book ChapterDOI
Origin and replication of defective interfering particles.
TL;DR: Defective interfering virus (DI) particles represent a major controlling element of virus replication and only amplify to interfering levels when the parent helper vims is abundant.
Journal ArticleDOI
Structural proteins of adenoviruses: II. Purification and characterization of the adenovirus type 2 fiber antigen☆
Ulf Pettersson,Stefan Höglund +1 more
TL;DR: Treatment of penton antigen with pyridine releases free vertex capsomers which are immunologically and morphologically intact and have the ability to induce cytopathic changes in KB-cell cultures.
Book ChapterDOI
Reproduction of Paramyxoviruses
TL;DR: Measles, canine distemper, and rinderpest viruses form a distinct subgroup on the basis of antigenicity, hemagglutinating characteristics, and lack of evidence for a virion-associated neuraminidase or neuraminic acid-containing cellular receptors, but it is now generally accepted that these viruses should be included in the paramyxovirus group because of their similar structural properties.
Book ChapterDOI
Defective Interfering Animal Viruses
Alice S. Huang,David Baltimore +1 more
TL;DR: Defective interfering particles were discovered three decades ago by von Magnus using the influenza virus system and a great deal was learned from their physiological interactions with the host and from their interference with the multiplication of “infectious” standard virus.
References
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Journal ArticleDOI
A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures
Robert G. Martin,Bruce N. Ames +1 more
TL;DR: Sucrose gradient centrifugation is found to be a suitable method for determining sedimentation coefficients of enzymes in protein mixtures and the sedimentation behavior of several of the enzymes in the pathway of histidine biosynthesis in S. typhimurium has been determined.
Journal ArticleDOI
Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels
A C Peacock,C W Dingman +1 more
Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Journal ArticleDOI
Defective T particles of vesicular stomatitis virus. I. Preparation, morphology, and some biologic properties.
TL;DR: The data strongly suggest that T is a distinct, truncated form of B which contains only a portion of the VSV genome, and is the physical equivalent of the transmissible interfering component of Cooper and Bellett (1959).
Journal ArticleDOI
Defective T particles of vesicular stomatitis virus. II. Biologic role in homologous interference.
Alice S. Huang,Robert R. Wagner +1 more
TL;DR: Defective T particles partially purified from undiluted-passage stocks of Indiana serotype vesicular stomatitis virus (VSV up) markedly interfered with growth of homotypic infectious B particles in Krebs-2 mouse ascites tumor cells.