Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TLDR
Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.Abstract:
Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome. Such particles are capable of specifically interfering with the growth of homologous, standard virus and may play a major part in the evolution of viral diseases.read more
Citations
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Journal ArticleDOI
Rapid evolution of RNA genomes
John J. Holland,Katherine R. Spindler,Katherine R. Spindler,Frank M. Horodyski,Elizabeth A. Grabau,Stuart T. Nichol,Scott VandePol +6 more
TL;DR: RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication, and high rates of replication reflected in rates of RNA genome evolution which can be more than a millionfold greater than the rates of the DNA chromosome evolution of their hosts.
Journal ArticleDOI
Prisoner's dilemma in an RNA virus
TL;DR: It is shown that the fitness of the high-multiplicity phage relative to their ancestors generates a pay-off matrix conforming to the prisoner's dilemma strategy of game theory, in which defection (selfishness) evolves, despite the greater fitness pay-offs that would result if all players were to cooperate.
Journal ArticleDOI
Why do RNA viruses recombine
TL;DR: There is little evidence that recombination is favoured by natural selection to create advantageous genotypes or purge deleterious mutations, as predicted if recombination functions as a form of sexual reproduction, and recombination may be a mechanistic by-product of the evolutionary pressures acting on other aspects of virus biology.
Book ChapterDOI
Molecular Characterization of Pestiviruses
Gregor Meyers,Heinz-Jürgen Thiel +1 more
TL;DR: One remarkable property of pestiviruses is the existence of two biotypes that were recognized according to morphological changes they cause during growth in tissue culture cells, which arise by nonhomologous RNA recombination.
Book
The Evolution and Emergence of RNA Viruses
TL;DR: The evolution and emergence of hantaviruses is more complex than previously anticipated, and may serve as a realistic model for other viral groups.
References
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Journal ArticleDOI
An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.
Journal ArticleDOI
Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy.
TL;DR: The successful isolation of the presumed aetiological agent of SSPE is described and electron microscopic evidence of paramyxovirus-like particles and nucleocapsids in brain biopsies is described.
Book ChapterDOI
Incomplete Forms of Influenza Virus
TL;DR: This chapter describes the experimental conditions required for the production of fully active and incomplete influenza virus and discusses the various hypotheses about the mechanism responsible for the formation of incomplete virus along with the nature and origin of the virus.
Journal ArticleDOI
Ribonucleic Acid Synthesis of Vesicular Stomatitis Virus I. Species of Ribonucleic Acid Found in Chinese Hamster Ovary Cells Infected with Plaque-forming and Defective Particles
TL;DR: Observations begin to establish a molecular basis for understanding the ability of T particles to interfere with the growth of B particles in Chinese hamster ovary cells.