Journal ArticleDOI
Proposed Mechanism of Force Generation in Striated Muscle
A. F. Huxley,R. M. Simmons +1 more
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Recordings of the change in tension in striated muscle after a sudden alteration of the length have made it possible to suggest how the force between the thick and thin muscle filaments may be generated.Abstract:
Recordings of the change in tension in striated muscle after a sudden alteration of the length have made it possible to suggest how the force between the thick and thin muscle filaments may be generated.read more
Citations
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Brownian motors: noisy transport far from equilibrium
TL;DR: In this paper, the main emphasis is put on directed transport in so-called Brownian motors (ratchets), i.e. a dissipative dynamics in the presence of thermal noise and some prototypical perturbation that drives the system out of equilibrium without introducing a priori an obvious bias into one or the other direction of motion.
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Single myosin molecule mechanics: piconewton forces and nanometre steps
TL;DR: A new in vitro assay using a feedback enhanced laser trap system allows direct measurement of force and displacement that results from the interaction of a single myosin molecule with a single suspended actin filament.
Journal ArticleDOI
Structure of the actin-myosin complex and its implications for muscle contraction.
Ivan Rayment,Hazel M. Holden,Michael Whittaker,Christopher B. Yohn,Michael Lorenz,Kenneth C. Holmes,Ronald A. Milligan +6 more
TL;DR: The spatial relation between the ATP binding pocket on myosin and the major contact area on actin suggests a working hypothesis for the crossbridge cycle that is consistent with previous independent structural and biochemical studies.
Journal ArticleDOI
The Way Things Move: Looking Under the Hood of Molecular Motor Proteins
TL;DR: The microtubule-based kinesin motors and actin-based myosin motors generate motions associated with intracellular trafficking, cell division, and muscle contraction using a common core structure and convert energy from adenosine triphosphate into protein motion using a similar conformational change strategy.
Journal ArticleDOI
Bead movement by single kinesin molecules studied with optical tweezers
TL;DR: The results of this study are consistent with a model in which kinesin detaches briefly from the microtubule during a part of each mechanochemical cycle, rather than a models in whichKinesin remains bound at all times.
References
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Journal ArticleDOI
Viscosity, Plasticity, and Diffusion as Examples of Absolute Reaction Rates
TL;DR: The theory of reaction rates yields an equation for absolute viscosity applicable to cases involving activation energies where the usual theory of energy transfer does not apply as mentioned in this paper, which provides an explanation of the law of rectilinear diameters of Cailletet and Mathias.
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The Mechanism of Muscular Contraction
TL;DR: There is now a real possibility of solving the problem in complete detail, provided a way can be found to crystallize a recently purified globular subfragment of the myosin molecule, and some apparently paradoxical properties of the system are revealed.
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Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle.
TL;DR: The results obtained show that the filaments are structurally polarized, and in muscle are arranged so that all of them attached on one side of a given Z-line point in one direction, whilst those on the other are oppositely oriented.
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An analysis of the mechanical components in frog's striated muscle.
B. R. Jewell,D. R. Wilkie +1 more
TL;DR: J. R. Wilkie striated muscle An analysis of the mechanical components in frog's This information is current as of March 19, 2008 and has been published is the official journal of The Journal of Physiology Online.
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The Mechanics of Active Muscle
TL;DR: At an initial extension not greater than that at which the developed tension is a maximum the system is ‘stable’ and the tension reaches its full value sharply: at extensions on the outer side of the maximum the System is “unstable” and a long slow creep of rising tension occurs.