Radioguided surgery with β radiation: a novel application with Ga68.
Francesco Collamati,V. Bocci,Paolo Castellucci,Micol De Simoni,Micol De Simoni,Stefano Fanti,Riccardo Faccini,Riccardo Faccini,Alessandro Giordano,Daria Maccora,Carlo Mancini-Terracciano,M. Marafini,R. Mirabelli,R. Mirabelli,Silvio Morganti,Riccardo Schiavina,Teresa Scotognella,Giacomo Traini,Giacomo Traini,Elena Solfaroli Camillocci,Elena Solfaroli Camillocci +20 more
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TLDR
The possibility to extendRadio Guided Surgery cases to 68Ga, a β+ emitting isotope widely used today in nuclear medicine, is discussed, analysing their 68Ga-PSMA PET images to asses if the molecule uptake is enough to apply this technique.Abstract:
Radio Guided Surgery is a technique helping the surgeon in the resection of tumors: a radiolabeled tracer is administered to the patient before surgery and then the surgeon evaluates the completeness of the resection with a handheld detector sensitive to emitted radiation. Established methods rely on γ emitting tracers coupled with γ detecting probes. The efficacy of this technique is however hindered by the high penetration of γ radiation, limiting its applicability to low background conditions. To overtake such limitations, a novel approach to RGS has been proposed, relying on β− emitting isotopes together with a dedicated β probe. This technique has been proved to be effective in first ex-vivo trials. We discuss in this paper the possibility to extend its application cases to 68Ga, a β+ emitting isotope widely used today in nuclear medicine. To this aim, a retrospective study on 45 prostatic cancer patients was performed, analysing their 68Ga-PSMA PET images to asses if the molecule uptake is enough to apply this technique. Despite the expected variability both in terms of SUV (median 4.1, IQR 3.0–6.1) and TNR (median 9.4, IQR 5.2–14.6), the majority of cases have been found to be compatible with β-RGS with reasonable injected activity and probing time (5 s).read more
Citations
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Recent advances in nuclear and hybrid detection modalities for image-guided surgery.
Matthias N. van Oosterom,D.D.D. Rietbergen,Mick M. Welling,Henk G. van der Poel,Tobias Maurer,Fijs W. B. van Leeuwen +5 more
TL;DR: This review has aimed to provide a comprehensive update of the most recent advances in the field of radioguided surgery, covering all aspects of radioisotopes that emit γ, β+, and/or β− radiation.
Journal ArticleDOI
Gold nanoparticles and nanorods in nuclear medicine: A mini review
Daria Maccora,Valentina Dini,Chiara Battocchio,Ilaria Fratoddi,Antonella Cartoni,Dante Rotili,Massimo Castagnola,Riccardo Faccini,Isabella Bruno,Teresa Scotognella,Alessandro Giordano,Iole Venditti +11 more
TL;DR: This review focuses on recent advances regarding the use of gold nanoparticles and nanorods in nuclear medicine with special attention on the dimensions and functionalizations that are most used to attain an enhanced performance of gold engineered nanomaterials.
Journal ArticleDOI
A DROP-IN beta probe for robot-assisted 68 Ga-PSMA radioguided surgery: first ex vivo technology evaluation using prostate cancer specimens
Francesco Collamati,Matthias N. van Oosterom,Matthias N. van Oosterom,Micol De Simoni,Micol De Simoni,Riccardo Faccini,Riccardo Faccini,M. Fischetti,M. Fischetti,Carlo Mancini Terracciano,Carlo Mancini Terracciano,R. Mirabelli,R. Mirabelli,Roberto Moretti,Roberto Moretti,Judith olde Heuvel,Elena Solfaroli Camillocci,Elena Solfaroli Camillocci,Florian van Beurden,Florian van Beurden,Henk G. van der Poel,Renato A. Valdés Olmos,Pim J. van Leeuwen,Fijs W. B. van Leeuwen,Fijs W. B. van Leeuwen,Silvio Morganti +25 more
TL;DR: The feasibility of beta-radioguided surgery in a robotic context by means of a DROP-INβ detector is demonstrated and this technique could provide a valuable tool in detecting tumor remnants on the prostate surface and in confirmation of PSMA-PET positive lymph nodes.
Journal ArticleDOI
99mTc-68Ga-ICG-Labelled Macroaggregates and Nanocolloids of Human Serum Albumin: Synthesis Procedures of a Trimodal Imaging Agent Using Commercial Kits.
Marco G. Persico,Manuela Marenco,Gianluca De Matteis,Giulia Manfrinato,Giorgio Cavenaghi,Adele Sgarella,Carlo Aprile,Lorenzo Lodola +7 more
TL;DR: A trimodal SLN/ROLL targeting agent (99mTc-68Ga-ICG) with commercially available kits of macroaggregated or nanocolloidal albumin (MA/NC-HSA) is studied to optimise the labelling and tagging of these two radiopharmaceuticals and assess their yields and stability.
Journal ArticleDOI
Characterisation of a β detector on positron emitters for medical applications
Francesco Collamati,R Moretti,L Alunni-Solestizi,V. Bocci,Antonella Cartoni,Angela Collarino,M. De Simoni,Riccardo Faccini,M Fischetti,Alessandro Giordano,Daria Maccora,Carlo Mancini-Terracciano,R Mirabelli,Teresa Scotognella,E Solfaroli-Camillocci,G Traini,Silvio Morganti +16 more
TL;DR: A new prototype of an intraoperative β particle detector, based on a high light yield and low density organic scintillator, that seems to have promising characteristics to perform RGS also with β+ emitting isotopes.
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