Journal ArticleDOI
Rapid heavy metal sensing platform: A case of triple signal amplification strategy for the sensitive detection of serum copper
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TLDR
In this article, a triple signal-amplified electrochemical sensing platform based on metal-dependent DNAzymes was fabricated for sensitive determination of heavy metals in serum (copper as a model target).About:
This article is published in Analytica Chimica Acta.The article was published on 2021-10-09. It has received 6 citations till now. The article focuses on the topics: Detection limit.read more
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A low-noise ratiometric fluorescence biosensor for detection of Pb2+ based on DNAzyme and exonuclease III–assisted cascade signal amplification
TL;DR: A low-noise ratiometric fluorescence biosensor developed based on Pb2+-dependent DNAzyme and exonuclease III (Exo III)–assisted cascade signal amplification has great potential in the monitoring of various targets.
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Traditional and new applications of the HCR in biosensing and biomedicine.
TL;DR: The hybridization chain reaction (HCR) as mentioned in this paper is a very popular isothermal nucleic acid amplification technology for various biosensing and biomedicine fields, however, it has some inevitable shortcomings of relatively slow kinetics, low cell internalization efficiency, weak biostability of DNA probes and uncontrollable reaction in these applications.
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Application of Hybridization Chain Reaction (HCR) in Electrochemical Analysis
TL;DR: This review highlights the progress in HCR-based electrochemical biosensors which are divided based on the types of signal reporters.
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Label- and enzyme-free plasmon-enhanced single molecule fluorescence detection of HIV DNA fragments based on a catalytic hairpin assembly.
Ke Shi,Na Na,Jin Ouyang +2 more
TL;DR: Wang et al. as discussed by the authors developed a label and enzyme-free single molecule fluorescence counting strategy for HIV DNA fragments detection, which consists of a 5' terminal connected with a triangular gold nanoplate, 3' terminal rich in guanine hairpin probe (HP1) and a hairpin probing HP2 complementary to the partial sequence of HP1.
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Journal ArticleDOI
A highly sensitive and selective catalytic DNA biosensor for lead ions [9]
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Metal Sensing by DNA
TL;DR: Each metal ion and the known DNA sequences for its sensing are reviewed and the fundamental aspect of metal binding is emphasized, emphasizing the distinct chemical property of each metal.
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Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability
TL;DR: Next-generation DNA HCR amplifiers are designed that maximize the free energy benefit per polymerization step while preserving the kinetic trapping property that underlies conditional polymerization, dramatically increasing signal gain, reducing reagent cost, and improving reagent durability.
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Functional DNA Nanostructures for Theranostic Applications
TL;DR: DNA tetrahedra tailored with CpG oligonucleotide drugs have shown greatly improved immunostimulatory effects that makes them a highly promising nanomedicine and it is believed these functionalized DNA nanostructures can be a type of intelligent theranostic nanodevice for simultaneous sensing, diagnosis, and therapy inside the cell.