Journal ArticleDOI
RBE for carbon track-segment irradiation in cell lines of differing repair capacity
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TLDR
The carbon RBE LET relationship for inactivation is shifted to higher LET values compared with protons and alpha-particles.Abstract:
Purpose: The LET position of the RBE maximum and its dependence on the cellular repair capacity was determined for carbon ions. Hamster celllines of differing repair capacity were irradiated with monoenergetic carbon ions. RBE values for cell inactivation at different survival levels were determined and the differences in the RBE-LET patterns were compared with the individual sensitivity to photon irradiation of the different cell lines. Material and methods: Three hamster cell lines, the wild-type cell lines V79 and CHO-K1 and the radiosensitive CHO mutant xrs5, were irradiated with carbon ions of different energies (2.4-266.4MeV/u) and LET values (13.7-482.7keV/mum) and inactivation data were measured in comparison to 250kV x-rays. Results: For the repair-proficient cell lines a RBE maximum was found at LET values between 150 and 200keV/mum. For the repair-deficient cell line the RBE failed to show a maximum and decreased continuously for LET values above 100keV/mum. Conclusions: The carbon RBE-LET rela...read more
Citations
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Heavy-ion tumor therapy: Physical and radiobiological benefits
TL;DR: Results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities, and the progress in heavy-ion therapy is reviewed, including physical and technical developments, radiobiological studiesmore and models, as well as radiooncological studies.
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Charged particles in radiation oncology
Marco Durante,Jay S. Loeffler +1 more
TL;DR: In this paper, a review of particle therapy in radiotherapy is presented, and the authors identify and discuss the research questions that have resulted with this technique, and conclude that the high costs of accelerators and beam delivery in particle therapy are justified by a clear clinical advantage.
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Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose.
TL;DR: A novel approach to treatment planning for heavy-ion radiotherapy based on the local effect model (LEM) which allows us to calculate the biologically effective dose not only for the target region but also for the entire irradiation volume.
Journal ArticleDOI
Tumor therapy with heavy charged particles
TL;DR: In this paper, the physical and biological basis of the action of ion beams in cells and tissues is briefly reviewed and the variation of radiobiological effectiveness as function of the radiation quality is presented.
Journal ArticleDOI
Quantification of the Relative Biological Effectiveness for Ion Beam Radiotherapy: Direct Experimental Comparison of Proton and Carbon Ion Beams and a Novel Approach for Treatment Planning
Thilo Elsässer,Wilma K. Weyrather,Thomas Friedrich,Marco Durante,Gheorghe Iancu,Michael Krämer,Gabriele Kragl,Gabriele Kragl,Stephan Brons,Marcus Winter,Klaus-Josef Weber,M. Scholz +11 more
TL;DR: The experimental data and the new modeling approach are supportive of the advantages of carbon ions as compared with protons for treatment-like field configurations, and the model represents a powerful tool for further optimization and utilization of the potential of ion beams in tumor therapy.
References
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Magnetic scanning system for heavy ion therapy
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Journal ArticleDOI
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
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TL;DR: The radiosensitive mutant xrs-6, derived from Chinese hamster ovary cells, is defective in DNA double-strand break repair and in ability to undergo V(D)J recombination, and results may also indicate a role for the Ku-DNA-dependent protein kinase complex in those same processes.
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Penny A. Jeggo,L.M. Kemp +1 more
TL;DR: One mutant strain, xrs-7, was cross-sensitive to all the DNA-damaging agents, but was proficient in the repair of single-strand breaks, and appears to represent new mutant phenotypes derived from cultured mammalian cell lines.
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Effects of different ionizing radiations on human cells in tissue culture. III. Experiments with cyclotron-accelerated alpha-particles and deuterons.
TL;DR: Results obtained from cyclotron-accelerated a-particles and deuterons show that in this region the RBE varies rapidly with LET, especially at low levels of damage.
Journal ArticleDOI
Inactivation of Human Kidney Cells by High-Energy Monoenergetic Heavy-Ion Beams
TL;DR: In this paper, fundamental data on the biological effects of monoenergetic beams of carbon (400 MeV/amu), neon, neon, and argon (570 MeV /amu) were presented.