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Reaction Acceleration Promoted by Partial Solvation at the Gas/Solution Interface
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The kinetics of organic reactions of different types in microvolumes (droplets, thin films, and sealed tubes) show effects of gas/solution interfacial area, reaction molecularity and solvent polarity as discussed by the authors.Abstract:
The kinetics of organic reactions of different types in microvolumes (droplets, thin films, and sealed tubes) show effects of gas/solution interfacial area, reaction molecularity and solvent polarity. Partial solvation at the gas/solution interface is a major contributor to the 104 -fold reaction acceleration seen in bimolecular but not unimolecular reactions in microdroplets. Reaction acceleration can be used to manipulate selectivity by solvent choice.read more
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Catalyst‐Free Three‐Component Petasis Reactions Accelerated in Microdroplets: Reaction Optimization and Senstive Detection by Mass Spectrometry
TL;DR: In this paper , a green and highly efficient microdroplet method was developed for accelerating the Petasis reaction, which obtained good yields without the need of any catalysts under mild reaction conditions.
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Kinetic Study of the Maillard Reaction in Thin Film Generated by Microdroplets Deposition
TL;DR: In this paper , the Maillard reaction kinetics in the confined volume of the thin film produced by ESI microdroplet deposition was studied by mass spectrometry and the almost exclusive formation of the Amadori product from the reaction of D-xylose and D-glucose toward L-glycine and L-lysine was demonstrated.
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Infrared Reflection-Absorption Spectroscopy of α-Keto Acids at the Air-Water Interface: Effects of Chain Length and Headgroup on Environmentally Relevant Surfactant Films.
TL;DR: In this article , the impact of the polar headgroup and alkyl tail length on the structure and morphology of organic monolayers at the air-water interfaces was examined, and it was shown that the structure of α-keto acids, both soluble and insoluble, at water surfaces is a compromise between van der Waals interactions of the hydrocarbon tail and hydrogen bonding interactions involving the polar group.
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High‐throughput Diversification of Complex Bioactive Molecules by Accelerated Synthesis in Microdroplets
TL;DR: In this article , an opioid agonist (PZM21) and an antagonist (naloxone) were diversified using three reactions important in medicinal chemistry: sulfur fluoride exchange (SuFEx) click reactions, imine formation reactions, and ene-type click reactions.
References
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Journal ArticleDOI
Gas-phase nucleophilic displacement reactions
Journal ArticleDOI
Organic Reactions in Microdroplets: Reaction Acceleration Revealed by Mass Spectrometry.
TL;DR: This Minireview introduces droplet and thin-film acceleration phenomena and summarizes recent methods applied to study accelerated reactions in confined-volume, high-surface-area solutions.
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Accelerated bimolecular reactions in microdroplets studied by desorption electrospray ionization mass spectrometry
TL;DR: In this article, it is shown that the environment in the microdroplet differs from that of the bulk: (i) the pH of the solution moves towards the extremes, (ii) the concentrations of the reagents increase, (iii) the relative surface area increases and collision frequencies increase.
Journal ArticleDOI
Enhanced chemical synthesis at soft interfaces: a universal reaction-adsorption mechanism in microcompartments
Ali Fallah-Araghi,Kamel Meguellati,Jean-Christophe Baret,Abdeslam El Harrak,Thomas Mangeat,Martin Karplus,Martin Karplus,Sylvain Ladame,Sylvain Ladame,Carlos M. Marques,Andrew D. Griffiths,Andrew D. Griffiths +11 more
TL;DR: Reaction thermodynamics is modified by compartmentalization at the mesoscale--without confinement on the molecular scale--leading to a universal mechanism for improving unfavorable reactions.