Recent developments in amide synthesis: direct amidation of carboxylic acids and transamidation reactions
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TLDR
In this article, a review of recent developments in the direct amidation of carboxylic acids and the interconversion of amides through transamidation is presented, as well as the possible mechanisms of the reactions.About:
This article is published in European Journal of Organic Chemistry.The article was published on 2013-11-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: Amide.read more
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Nonclassical Routes for Amide Bond Formation
TL;DR: The present review offers an overview of nonclassical (e.g., with no pre- or in situ activation of a carboxylic acid partner) approaches for the construction of amide bonds.
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Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
TL;DR: In this article, a review of coupling reagents for large-scale amide synthesis via the condensation of an acid and amine is presented, highlighting the benefits and drawbacks of each reagent on an industrial scale.
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Catalytic amide formation from non-activated carboxylic acids and amines
TL;DR: A comprehensive overview of homogeneous and heterogeneous catalytic methods is presented, covering biocatalysts, Lewis acid catalysts based on boron and metals as well an assortment of other types of catalysts.
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Polymer engineering based on reversible covalent chemistry: A promising innovative pathway towards new materials and new functionalities
TL;DR: In this article, a review of reversible covalent polymers is presented, which mainly consists of four parts, involving design and preparation: (i) the basis of reversible Covalent chemistry, (ii) rheology of reversible polymers, (iii) methods of construction of reversible polymer, and (iv) smart, adaptive properties offered by reversible chemistry, including self-healing, reprocessing, solid state recycling, and controllable degradation.
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Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
TL;DR: This overview shows how the overlap of previously unrelated areas of mechanochemical screening for API solid forms, organic synthesis by milling, and mechanochemical screenings for molecular recognition enables the emergence of a new research discipline in which different aspects of pharmaceutical and medicinal chemistry are addressed through mechanochemistry rather than through conventional solution-based routes.
References
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A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases.
TL;DR: The effective range of physicochemical properties presented here can be used in the design of drug-like combinatorial libraries as well as in developing a more efficient corporate medicinal chemistry library.
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Amide bond formation: beyond the myth of coupling reagents
Eric Valeur,Mark Bradley +1 more
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
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Amide bond formation and peptide coupling
TL;DR: In this article, the authors propose a method to solve the problem of "uniformity" in the literature: 1.0040−4020/$ doi:10.1016/
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Analysis of the reactions used for the preparation of drug candidate molecules.
TL;DR: The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies.
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Rethinking amide bond synthesis
TL;DR: A new generation of amide-forming reactions are reviewed and summarize their potential application to current synthetic challenges, including the development of catalytic amide formation, the synthesis of therapeutic peptides and the preparation of modified peptide and proteins.