Recent updates on incubation of drug craving: a mini-review
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A mini‐review of three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals and several key publications from the past year on behavioral and mechanistic findings related to incubated drug craving.Abstract:
Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini-review, we first discuss three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving. Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. Here, we first discuss three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving.read more
Citations
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Journal ArticleDOI
Synaptic mechanisms underlying persistent cocaine craving
TL;DR: Rodent studies of cue-induced cocaine craving during abstinence are discussed, with a focus on neuronal plasticity in the reward circuitry that maintains high levels of craving.
Book ChapterDOI
Animal models of drug relapse and craving: From drug priming-induced reinstatement to incubation of craving after voluntary abstinence.
TL;DR: Different animal models that have been used to study behavioral and neuropharmacological mechanisms of relapse-related phenomena and the potential implications of the recent developments of animal models of drug relapse after voluntary abstinence to the development of medications for relapse prevention are discussed.
Journal ArticleDOI
Animal models of addiction.
TL;DR: It is argued that animal models of voluntary drug intake—under nonoperant and operant conditions—and addiction models based on the Diagnostic and Statistical Manual of Mental Disorders are crucial and informative tools for the identification of pathological mechanisms, target identification, and drug development.
Journal ArticleDOI
Incubation of Cue-Induced Craving in Adults Addicted to Cocaine Measured by Electroencephalography
TL;DR: The late positive potential responses to drug cues, indicative of motivated attention, showed a trajectory similar to that reported in animal models, and the subjective assessment of baseline craving did not detect incubation of subjective cue-induced craving.
Journal ArticleDOI
Incubation of Cocaine Craving After Intermittent-Access Self-administration: Sex Differences and Estrous Cycle.
Céline Nicolas,Trinity I. Russell,Anne F. Pierce,Steeve Maldera,Amanda Holley,Zhi-Bing You,Margaret M. McCarthy,Yavin Shaham,Satoshi Ikemoto +8 more
TL;DR: In female rats, the time-dependent increase in drug seeking (incubation) is critically dependent on the estrous cycle phase, which is significantly higher during estrus than during non-estrus for intermittent drug access.
References
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Journal ArticleDOI
Neuroadaptation. Incubation of cocaine craving after withdrawal.
TL;DR: Behavioural evidence is provided from laboratory animals suggesting that the onset of craving is delayed and that craving does not decay, but rather increases progressively, over a two-month withdrawal period.
PatentDOI
FORMATION OF ACCUMBENS GluR2-LACKING AMPA RECEPTORS MEDIATES INCUBATION OF COCAINE CRAVING
TL;DR: In this paper, a method for ameliorating cue-induced cravings for an addictive substance in abstinent addicts by administering a compound capable of blockade of GluR2-lacking AMPA receptors was proposed.
Journal ArticleDOI
Neurobiology of the incubation of drug craving
Charles L. Pickens,Mikko Airavaara,Florence R. M. Theberge,Sanya Fanous,Bruce T. Hope,Yavin Shaham +5 more
TL;DR: Recent results that have identified important brain regions involved in the incubation of drug craving in rodents are discussed, as well as evidence for the underlying cellular mechanisms.
Journal ArticleDOI
Fos protein expression and cocaine-seeking behavior in rats after exposure to a cocaine self-administration environment
Janet L. Neisewander,David A. Baker,Rita A. Fuchs,Ly T.L. Tran-Nguyen,Art J. Palmer,John F. Marshall +5 more
TL;DR: The results suggest that different neural circuits may be involved in the incentive motivational effects of cocaine-paired environmental stimuli versus priming injections and that the anterior cingulate may be part of a common pathway for both.
Journal ArticleDOI
Central amygdala ERK signaling pathway is critical to incubation of cocaine craving
TL;DR: The role of the amygdala extracellular signal–regulated kinase (ERK) signaling pathway in the incubation of cocaine craving is explored, suggesting that drug craving incubates over time.