Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5.
Michael Schaefer,Timothy D. Plant,Alexander G. Obukhov,Thomas Hofmann,Thomas Gudermann,Günter Schultz +5 more
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mTRPC4 and mTRPC5 form nonselective cation channels that integrate signaling pathways from G-protein-coupled receptors and receptor tyrosine kinases independently of store depletion, which is inconsistent with those ofI CRAC, the most extensively characterized store-operated current.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-06-09 and is currently open access. It has received 410 citations till now. The article focuses on the topics: TRPC4 & TRPC Cation Channels.read more
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Store-operated calcium channels.
Anant B. Parekh,James W. Putney +1 more
TL;DR: The key electrophysiological features of I(CRAC) and other store-operated Ca(2+) currents and how they are regulated are described, and recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca( 2+) entry pathway are considered.
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An Introduction to TRP Channels
TL;DR: The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems.
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Transient Receptor Potential Cation Channels in Disease
TL;DR: An overview of the impact of TRP channels on the pathogenesis of several diseases is provided and several TRPs for which a causal pathogenic role might be anticipated are identified.
Journal ArticleDOI
The trp ion channel family
David E. Clapham,David E. Clapham,Loren W. Runnels,Loren W. Runnels,Carsten Strübing,Carsten Strübing +5 more
TL;DR: Three subgroups comprise the TRP channel family; the best understood of these mediates responses to painful stimuli, and other proposed functions include repletion of intracellular calcium stores, receptor-mediated excitation and modulation of the cell cycle.
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OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.
TL;DR: A new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart is identified and proposed as a candidate for a molecular sensor that confers osmosensitivity on mammalian cells.
References
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A new generation of Ca2+ indicators with greatly improved fluorescence properties.
TL;DR: A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+ using an 8-coordinate tetracarboxylate chelating site with stilbene chromophores that offer up to 30-fold brighter fluorescence.
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Store depletion and calcium influx
Anant B. Parekh,Reinhold Penner +1 more
TL;DR: The electrophysiological properties of the prototype store-operated current ICRAC are focused on, the regulatory mechanisms that control it are discussed, and recent advances toward the identification of molecular mechanisms involved in this ubiquitous and important Ca2+ entry pathway are considered.
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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
Thomas Hofmann,Alexander G. Obukhov,Michael Schaefer,Christian Harteneck,Thomas Gudermann,Günter Schultz +5 more
TL;DR: The molecular mechanism of store-depletion-independent activation of a subfamily of mammalian TRPC channels is described and it is found that hTRPC6 is a non-selective cation channel that is activated by diacylglycerol in a membrane-delimited fashion, independently of protein kinases C activated bydiacyl Glycerol.
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Calcium release-activated calcium current in rat mast cells.
Markus Hoth,Reinhold Penner +1 more
TL;DR: The selectivity of ICRAC was assessed by using fura‐2 as the dominant intracellular buffer and relating the absolute changes in the calcium‐sensitive fluorescence with the calcium current integral almost identical to the one determined for Ca2+ influx through voltage‐activated calcium currents in chromaffin cells, suggesting a similar selectivity.
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trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry
Xi Zhu,Meisheng Jiang,Michael Peyton,Guylain Boulay,Raymond S. Hurst,Enrico Stefani,Lutz Birnbaumer +6 more
TL;DR: It is proposed that trp homologs are subunits of CCE channels, not unlike those of classical voltage-gated ion channels.