Journal ArticleDOI
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research.
Adam J. Guastella,Ian B. Hickie,Margaret M. McGuinness,Margaret M. McGuinness,Melissa Otis,Melissa Otis,Elizabeth A. Woods,Elizabeth A. Woods,Hannah M. Disinger,Hannah M. Disinger,Hak-Kim Chan,Timothy F. Chen,Richard B. Banati,Richard B. Banati +13 more
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TLDR
A summary of factors that influence transmucosal nasal drug delivery, deposition, and their impact on bioavailability is provided, including variations in anatomy and resultant airflow dynamic, vascularisation, status of blood vessels, mode of spray application, gallenic formulation, and amount and method of administration.About:
This article is published in Psychoneuroendocrinology.The article was published on 2013-05-01. It has received 313 citations till now. The article focuses on the topics: Nasal spray & Nasal administration.read more
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Opportunities and challenges for intranasal oxytocin treatment studies in nonhuman primates
TL;DR: Comp contributions of the nonhuman primate model to the understanding of OT treatment are highlighted and unique challenges in administering OT to awake behaving primates are addressed.
Journal ArticleDOI
To mirror or not to mirror upon mutual gaze, oxytocin can pave the way: A cross-over randomized placebo-controlled trial.
TL;DR: While participants with high attachment avoidance initially displayed a reduced propensity to increase their motor resonance upon direct eye contact, a single dose of OXT was able to promote an otherwise avoidant individual's propensity to engage inMotor resonance upon a salient social cue such as eye contact.
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Effects of oxytocin administration on cue‐induced craving in co‐occurring alcohol use disorder and PTSD: a within‐participant randomized clinical trial
Christopher S. Stauffer,Nathan K. Meinzer,Tyler Morrison,Jin-Hui Wen,Lily Radanovich,David Leung,Andrea N. Niles,Aoife O'Donovan,Steven L. Batki,Joshua D. Woolley +9 more
TL;DR: The preliminary findings suggest that oxytocin does not affect cue-induced craving, and this results contribute to an ever-growing field of research investigating the effects of intranasal oxytoc in on the symptoms of substance use disorders.
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Cold face test-induced increases in heart rate variability are abolished by engagement in a social cognition task.
TL;DR: In this paper, the role of the vagus nerve in social cognition using the cold face test (facial cooling) was investigated and it was found that facial cooling increased the parasympathetic outflow and increased prefrontal inhibitory control.
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Musculoskeletal Pain and Brain Morphology: Oxytocin's Potential as a Treatment for Chronic Pain in Aging.
TL;DR: It is proposed that research on the use of intranasal OT administration as an intervention for chronic pain in older adults is needed and constitutes a promising future direction for this field.
References
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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
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Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
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The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
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Social effects of oxytocin in humans: context and person matter.
TL;DR: It is proposed that this literature can be informed by an interactionist approach in which the effects of oxytocin are constrained by features of situations and/or individuals.
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The neurobiology of pair bonding
Larry J. Young,Zuoxin Wang +1 more
TL;DR: Differential regulation of neuropeptide receptor expression may explain species differences in the ability to form pair bonds and have intriguing implications for the neurobiology of social attachment in the authors' own species.