Journal ArticleDOI
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research.
Adam J. Guastella,Ian B. Hickie,Margaret M. McGuinness,Margaret M. McGuinness,Melissa Otis,Melissa Otis,Elizabeth A. Woods,Elizabeth A. Woods,Hannah M. Disinger,Hannah M. Disinger,Hak-Kim Chan,Timothy F. Chen,Richard B. Banati,Richard B. Banati +13 more
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TLDR
A summary of factors that influence transmucosal nasal drug delivery, deposition, and their impact on bioavailability is provided, including variations in anatomy and resultant airflow dynamic, vascularisation, status of blood vessels, mode of spray application, gallenic formulation, and amount and method of administration.About:
This article is published in Psychoneuroendocrinology.The article was published on 2013-05-01. It has received 313 citations till now. The article focuses on the topics: Nasal spray & Nasal administration.read more
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Physiological effects induced by stimulation of cutaneous sensory nerves, with a focus on oxytocin
Journal ArticleDOI
The role of oxytocin in delay of gratification and flexibility in non-social decision making
Georgia Eleni Kapetaniou,Matthias A. Reinhard,Patricia Christian,Andrea Jobst,Philippe N. Tobler,Philippe N. Tobler,Frank Padberg,Alexander Soutschek +7 more
TL;DR: In this article, the impact of intranasal oxytocin (24 IU) on core aspects of human social (inequity aversion) and non-social decision making (delay of gratification and cognitive flexibility) in 49 healthy volunteers (within-subject design).
Journal ArticleDOI
Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action
Shuxia Yao,Keith M. Kendrick +1 more
TL;DR: Overall, it is concluded that while some functional effects of intranasal oxytocin and vasopressin in the domain of social cognition may result from direct penetration into the brain following intran asal administration, others may be contributed by the neuropeptides either entering the peripheral circulation and crossing the blood–brain barrier and/or producing vagal stimulation via peripheral receptors.
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Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.
Christopher S. Stauffer,Christopher S. Stauffer,Christopher S. Stauffer,Jenna M. Moschetto,Scott McKernan,Nathan K. Meinzer,Chavy Chiang,Rachel Rapier,Elaine Hsiang,Jerika C. Norona,Brian Borsari,Joshua D. Woolley +11 more
TL;DR: This evidence, and the lack of any serious adverse events, suggests that oxytocin may safely increase treatment attendance, and one possible mechanism by which it may do so is its modulation of the autonomic nervous system.
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Early Environments Shape Neuropeptide Function: The Case of Oxytocin and Vasopressin.
Adi Perry-Paldi,Gilad Hirschberger,Ruth Feldman,Orna Zagoory-Sharon,Shira Buchris Bazak,Tsachi Ein-Dor +5 more
TL;DR: This work shows that early life stress is associated with change in the core function of OT and AVP in evolutionary predictable ways, and demonstrates the plasticity of neuropeptide functioning that mirrors the variance in human social-emotional functioning.
References
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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
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Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
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The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
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Social effects of oxytocin in humans: context and person matter.
TL;DR: It is proposed that this literature can be informed by an interactionist approach in which the effects of oxytocin are constrained by features of situations and/or individuals.
Journal ArticleDOI
The neurobiology of pair bonding
Larry J. Young,Zuoxin Wang +1 more
TL;DR: Differential regulation of neuropeptide receptor expression may explain species differences in the ability to form pair bonds and have intriguing implications for the neurobiology of social attachment in the authors' own species.