Journal ArticleDOI
Reduction of a 7,12-dimethylbenz[a]anthracene DNA adduct in rat mammary tissue in vivo when pretreated with tamoxifen.
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TLDR
The effects of TAM pretreatment on mammary DNA adducts of the model carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA), in the female rats suggest that TAM given to women prior to the development of breast cancer may modulate the impact of environmental exposures, for example, tobacco smoke.About:
This article is published in Toxicology Letters.The article was published on 2002-06-07. It has received 2 citations till now. The article focuses on the topics: DNA adduct & DMBA.read more
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Book ChapterDOI
9 – cherenkov counting
TL;DR: Cherenkov radiation as discussed by the authors is a phenomenon in which a charged particle travels through a transparent medium at a speed greater than the speed of light in that medium, which is referred to as Cherenkov Radiation.
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Journal ArticleDOI
Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
TL;DR: Tamoxifen decreases the incidence of invasive and noninvasive breast cancer and its use as a breast cancer preventive agent is appropriate in many women at increased risk for the disease.
Journal ArticleDOI
Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.
TL;DR: A minor modification of this procedure, entailing the postincubation of DNA digests with Penicillium citrinum nuclease P1 before 32P-labeling, enhanced the technique's sensitivity to 1 adduct in approximately 10(10) nucleotides for a 10-micrograms DNA sample.
Journal ArticleDOI
Weighing the Risks and Benefits of Tamoxifen Treatment for Preventing Breast Cancer
Mitchell H. Gail,Joseph P. Costantino,John Bryant,Robert T. Croyle,Laurence S. Freedman,Kathy J. Helzlsouer,Victor G. Vogel +6 more
TL;DR: Tamoxifen is most beneficial for younger women with an elevated risk of breast cancer, and the quantitative analyses presented can assist health care providers and women in weighing the risks and benefits of tamoxIFen for reducing breast cancer risk.
Book ChapterDOI
Comparative study of human and rat mammary tumorigenesis.
Jose Russo,Barry A. Gusterson,Adrianne E. Rogers,Irma H. Russo,Sefton R. Wellings,Matthew J. Van Zwieten +5 more
TL;DR: Lower risk of breast cancer has been reported in women that have had an early full-term pregnancy and among all of these factors, the development of Breast cancer is influenced by the reproductive history of the individual.
Journal Article
Biological and molecular bases of mammary carcinogenesis.
Jose Russo,Irma H. Russo +1 more