Journal ArticleDOI
Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation
TLDR
Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of 14C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute.Abstract:
Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of (14)C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute. Cross circulation for 7 hours or less was ineffective.read more
Citations
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Journal ArticleDOI
Liver regeneration: from myth to mechanism
Rebecca Taub,Rebecca Taub +1 more
TL;DR: The numerous cytokine- and growth-factor-mediated pathways that are involved in regulating liver regeneration are being successfully dissected using molecular and genetic approaches.
Journal ArticleDOI
Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats.
TL;DR: Results suggest that hepatotropin is a new growth factor that did not stimulate DNA synthesis in cultured hepatocytes and was additive with that of insulin plus epidermal growth factor.
Journal ArticleDOI
Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure.
Eiichi Gohda,Hirohito Tsubouchi,Hiroyuki Nakayama,Shuichi Hirono,Osamu Sakiyama,Kozo Takahashi,Hiroomi Miyazaki,Shuli Hashimoto,Yasushi Daikuhara +8 more
TL;DR: HGF stimulates proliferation of cultured hepatocytes more effectively than human epidermal growth factor (hEGF) or insulin, and the effect of hHGF is additive or synergistic with the maximal effects of hEGF and insulin.
Journal ArticleDOI
Liver Regeneration after Partial Hepatectomy: Critical Analysis of Mechanistic Dilemmas
TL;DR: The liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration and many aspects of the signaling mechanisms involved in hepatic regeneration are under active investigation.
Journal ArticleDOI
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration.
Wendong Huang,Ke Ma,Jun Zhang,Mohammed Qatanani,James M. Cuvillier,Jun Liu,Bingning Dong,Xiongfei Huang,David D. Moore +8 more
TL;DR: It is proposed that FXR activation by increased bile acid flux is a signal of decreased functional capacity of the liver, and may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth.
References
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Journal ArticleDOI
Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.
Book ChapterDOI
Regeneration of mammalian liver.
TL;DR: The chapter reviews experimental studies on the homeostatic control of hepatic growth, as exemplified primarily by regeneration in response to partial hepatectomy, with particular attention to the first cycle of cellular growth and division.
Journal Article
The Rate of Incorporation of Labeled Thymidine into the Deoxyribonucleic Acid of Regenerating Rat Liver in Relation to the Amount of Liver Excised
TL;DR: In 1- to 15-month-old rats the rate of DNA labeling increases logarithmically in direct proportion to the amount of liver excised at the peak period (also, in young adults at least, at the plateau), except that, if the liver loss exceeds a certain critical amount, which differs with age, some additional mechanism comes into play, raising the baseline and resulting in higher levels of labeled thymidine incorporation.
Journal ArticleDOI
Removal of the impurities, nucleic acid and polysaccharide, from tuberculin protein
TL;DR: Both of these substances may be considered impurities and should be eliminated, if possible, in the purification of theprotein, especially since the presence of the nucleic acid modified many of the physicochemical properties of the protein, such as isoelectric point, electrophoretic mobilities, and solubilities.
Journal Article
Effect of partial hepatectomy on dna synthesis and mitosis in heterotopic partial autografts of rat liver.
TL;DR: It is confirmed that portal blood and increased hepatic blood flow are unnecessary for proliferation of hepatocytes, consistent with a regulatory mechanism controlling hepatocytic proliferation, active throughout the body and distributed through the systemic circulation (blood-borne).