Journal ArticleDOI
Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans
John Sulston,John G. White +1 more
TLDR
The role of cell-cell interaction in the postembryonic development of nongonadal tissues in the nematode Caenorhabditis elegans has been explored by selective cell ablation with a laser microbeam and examples have been found of induction and of regulation in cell lineage and fate.About:
This article is published in Developmental Biology.The article was published on 1980-08-01. It has received 514 citations till now. The article focuses on the topics: Caenorhabditis elegans.read more
Citations
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Journal ArticleDOI
The structure of the nervous system of the nematode Caenorhabditis elegans
TL;DR: The structure and connectivity of the nervous system of the nematode Caenorhabditis elegans has been deduced from reconstructions of electron micrographs of serial sections as discussed by the authors.
Journal ArticleDOI
The embryonic cell lineage of the nematode Caenorhabditis elegans.
TL;DR: It is concluded that the cell lineage itself, complex as it is, plays an important role in determining cell fate and is demonstrated to demonstrate substantial cell autonomy in at least some sections of embryogenesis.
Journal ArticleDOI
A C. elegans mutant that lives twice as long as wild type
TL;DR: Finding that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type raises the possibility that the longevity of the dauer is not simply a consequence of its arrested growth, but instead results from a regulated lifespan extension mechanism that can be uncoupled from other aspects of dauer formation.
Journal ArticleDOI
Genetic control of programmed cell death in the nematode C. elegans
H. M. Ellis,H R Horvitz +1 more
TL;DR: Ced-3 and ced-4 mutants appear grossly normal in morphology and behavior, indicating that programmed cell death is not an essential aspect of nematode development.
Journal ArticleDOI
Odorant-selective genes and neurons mediate olfaction in C. elegans
TL;DR: Through laser ablation, chemosensory neurons that detect volatile odorants are identified and it is shown that the nematode C. elegans might have senses that correspond to smell and taste, respectively.
References
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Journal ArticleDOI
The genetics of caenorhabditis elegans
TL;DR: In this paper, the authors describe methods for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm.
Journal ArticleDOI
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
John Sulston,H.R. Horvitz +1 more
TL;DR: These cell lineages range in length from one to eight sequential divisions and lead to significant developmental changes in the neuronal, muscular, hypodermal, and digestive systems and are determined by direct observation of the divisions, migrations, and deaths of individual cells in living nematodes.
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The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans
Judith Kimble,David Hirsh +1 more
TL;DR: Variation in the hermaphrodite lineage suggests that cell-cell interaction may play a more significant role in organisms that develop by invariant lineages than has hitherto been considered.
Journal ArticleDOI
The structure of the ventral nerve cord of Caenorhabditis elegans
TL;DR: The nervous system of Caenorhabditis elegans is arranged as a series of fibre bundles which run along internal hypodermal ridges and three of the motor neurone classes receive their synaptic input from a set of interneurones coming from the nerve ring.