Regulation of rat growth hormone receptor gene expression.
TLDR
A cDNA encoding the growth hormone (GH) receptor was cloned from rat liver and expression in liver, kidney, heart and muscle was developmentally regulated, being low at birth and rising to adult levels in 5 weeks.About:
This article is published in Journal of Biological Chemistry.The article was published on 1989-06-15 and is currently open access. It has received 477 citations till now. The article focuses on the topics: Receptor & Solution hybridization.read more
Citations
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The prolactin/growth hormone receptor family.
TL;DR: It is doubtful that one unifying mechanism of action will be found for this hormone, as several potential components of the signal transduction pathways have been identified, but as yet none has clearly been shown to be able to mimic the effect of PRL or GH.
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Growth hormone and the heart.
TL;DR: Evidence from laboratory models shows that GH induces mRNA expression for specific contractile proteins and myocyte hypertrophy, which provides plausible explanations for the cardiac abnormalities observed in clinical settings of excessive or defective GH production and support a role of GH in the maintenance of a normal cardiac structure and performance.
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Gigantism in mice lacking suppressor of cytokine signalling-2
Donald Metcalf,Christopher J. Greenhalgh,Elizabeth M. Viney,Tracy A. Willson,Robyn Starr,Nicos A. Nicola,Douglas J. Hilton,Warren S. Alexander +7 more
TL;DR: Characteristics of deregulated growth hormone and insulin-like growth factor-I (IGF-I) signalling were observed in SOCS-2-deficient mice, indicating that SOCS -2 may have an essential negative regulatory role in the growth hormone/IGf-I pathway.
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The role of liver-derived insulin-like growth factor-I.
Claes Ohlsson,Subburaman Mohan,Klara Sjögren,Åsa Tivesten,Jörgen Isgaard,Olle Isaksson,John-Olov Jansson,John-Olov Jansson,Johan Svensson +8 more
TL;DR: It is proposed here that liver-derived circulating IGF-I and local bone-derived IGF- I to some extent have overlapping growth-promoting effects and might have the capacity to replace each other (= redundancy) in the maintenance of normal longitudinal bone growth.
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Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity
Fabrice Gouilleux,C Pallard,Isabelle Dusanter-Fourt,Hiroshi Wakao,Lars-Arne Haldosén,Gunnar Norstedt,D Levy,B Groner +7 more
TL;DR: The results suggest that MGF‐Stat5 regulates physiological processes in mammary epithelial cells, as well as in hematopoietic cells.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
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Growth hormone receptor and serum binding protein: purification, cloning and expression
David W. Leung,Steven A. Spencer,George Cachianes,R. Glenn Hammonds,Carol Collins,William J. Henzel,Ross Barnard,Michael J. Waters,William I. Wood +8 more
TL;DR: The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.