Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states.
TLDR
The molecular mechanisms underlying the presynaptic and postsynaptic alterations in GABAergic and glutamatergic inputs to PVN presympathetic neurons in hypertension are discussed and the ability of exercise training to correct sympathetic hyperactivity is discussed.Abstract:
The hypothalamic paraventricular nucleus (PVN) is a unique and important brain region involved in the control of cardiovascular, neuroendocrine, and other physiological functions pertinent to homeo...read more
Citations
More filters
Journal ArticleDOI
The extended autonomic system, dyshomeostasis, and COVID-19.
TL;DR: Testable hypotheses derived from these concepts are that biomarkers of EAS activation correlate with clinical and pathophysiologic data and predict outcome in COVID-19 and that treatments targeting specific abnormalities identified in individual patients may be beneficial.
Journal ArticleDOI
ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons.
TL;DR: The contrasting impact of ACE2 and ADAM17 on neuronal excitability of presympathetic neurons within the paraventricular nucleus and the consequences of this mutual regulation in the context of neurogenic hypertension are demonstrated.
Journal ArticleDOI
Neuronal Networks in Hypertension: Recent Advances.
Patrice G. Guyenet,Ruth L. Stornetta,George M. P. R. Souza,Stephen B. G. Abbott,Virginia L. Brooks +4 more
TL;DR: The brain regions that cause heightened sympathetic nerve activity in animal models of neurogenic hypertension are examined, and the triggers responsible for the changes in neuronal activity within these regions are discussed.
Journal ArticleDOI
How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives.
TL;DR: This perspective piece proposes that the integrative physiological and systems biological viewpoints about homeostasis reflect different epistemologies, different philosophies of knowledge, and predicts rapprochement of integrative physiology with systems biology.
Journal ArticleDOI
Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining.
Tryfonas Tofas,Dimitrios Draganidis,Chariklia K. Deli,Kalliopi Georgakouli,Ioannis G. Fatouros,Athanasios Z. Jamurtas +5 more
TL;DR: It is suggested that exercise training, either cardiovascular or resistance or even a combination of them, is a promising, safe and efficient tool in the prevention and treatment of CVDs.
References
More filters
Journal ArticleDOI
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
Journal ArticleDOI
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
TL;DR: In neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.
Journal ArticleDOI
Direct hypothalamo-autonomic connections.
Journal ArticleDOI
Cation–chloride co-transporters in neuronal communication, development and trauma
TL;DR: The cation-chloride co-transporters (CCCs) have been identified as important regulators of neuronal Cl- concentration, and recent work indicates that CCCs play a key role in shaping GABA- and glycine-mediated signaling, influencing not only fast cell-to-cell communication but also various aspects of neuronal development, plasticity and trauma.
Journal ArticleDOI
The Role of the GluR2 Subunit in AMPA Receptor Function and Synaptic Plasticity
TL;DR: Recent data highlighting the novel and important roles of GluR2 in synaptic function and plasticity are brought together.