Journal ArticleDOI
Cation–chloride co-transporters in neuronal communication, development and trauma
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TLDR
The cation-chloride co-transporters (CCCs) have been identified as important regulators of neuronal Cl- concentration, and recent work indicates that CCCs play a key role in shaping GABA- and glycine-mediated signaling, influencing not only fast cell-to-cell communication but also various aspects of neuronal development, plasticity and trauma.About:
This article is published in Trends in Neurosciences.The article was published on 2003-04-01. It has received 816 citations till now. The article focuses on the topics: Ion channel.read more
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What we can do and what we cannot do with fMRI
TL;DR: An overview of the current state of fMRI is given, and the current understanding of the haemodynamic signals and the constraints they impose on neuroimaging data interpretation are presented.
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Variations on an inhibitory theme : phasic and tonic activation of GABA(A) receptors
Mark Farrant,Zoltan Nusser +1 more
TL;DR: This review considers the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability in the adult mammalian brain.
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
TL;DR: It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
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GABA regulates synaptic integration of newly generated neurons in the adult brain
TL;DR: This study identifies an essential role for GABA in the synaptic integration of newly generated neurons in the adult brain, and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in which newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.
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NKCC1 transporter facilitates seizures in the developing brain
Volodymyr Dzhala,Delia M. Talos,Dan A Sdrulla,Audrey C. Brumback,Gregory C. Mathews,Tim A. Benke,Eric Delpire,Frances E. Jensen,Kevin J. Staley +8 more
TL;DR: Evidence that NKCC1 facilitates seizures in the developing brain is provided and indications that bumetanide should be useful in the treatment of neonatal seizures are indicated.
References
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Clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
TL;DR: The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved and modifications are incorporated into a new program, CLUSTAL W, which is freely available.
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Ischemic Cell Death in Brain Neurons
TL;DR: A major unifying thread of the review is a consideration of how the changes occurring during and after ischemia conspire to produce damaging levels of free radicals and peroxynitrite to activate calpain and other Ca(2+)-driven processes that are damaging, and to initiate the apoptotic process.
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Molecular Bases for Circadian Clocks
TL;DR: It used to be that research in chronobiology moved biochemical functions [transcriptional activators], the along at a gentlemanly pace, but by mid 1997 the word in determining what the authors perceive as time was PASWCCLK.
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The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
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Combining evolutionary information and neural networks to predict protein secondary structure.
Burkhard Rost,Chris Sander +1 more
TL;DR: This work extends the previous three‐level system of neural networks by using additional input information derived from multiple alignments using a position‐specific conservation weight as part of the input to increase performance and greatly increased accuracy.