Regulation of the human thromboxane A2 receptor gene by Sp1, Egr1, NF-E2, GATA-1, and Ets-1 in megakaryocytes
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TLDR
In this paper, the authors identify factors regulating PRm1 within the megakaryocytic human erythroleukemia 92.1.7 cell line, and demonstrate that Sp1, Egr1, and NF-E2 regulate core Prm1 activity, whereas GATA-1 and Ets-1 act as critical upstream activators.About:
This article is published in Journal of Lipid Research.The article was published on 2008-12-01 and is currently open access. It has received 22 citations till now. The article focuses on the topics: Upstream activating sequence & Activator (genetics).read more
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Journal ArticleDOI
Identification of an Interaction between the TPα and TPβ Isoforms of the Human Thromboxane A2 Receptor with Protein Kinase C-related Kinase (PRK) 1 IMPLICATIONS FOR PROSTATE CANCER
Elizebeth C. Turner,David Kavanagh,Eamon P. Mulvaney,Caitriona McLean,Katarina Wikström,Helen M. Reid,B. Therese Kinsella +6 more
TL;DR: Considering the role of TXA2 as a potent mediator of RhoA signaling, the identification of PRK1 as a bona fide interactant of TPα/TPβ, and leading to H3 Thr11 phosphorylation to regulate cell migration, has broad functional significance such as within the vasculature and in neoplasms in which bothPRK1 and the TPs are increasingly implicated.
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Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer
TL;DR: Data suggest that TXA2 acts as both a neoplastic and epigenetic regulator and provides a mechanistic explanation, at least in part, for the prophylactic benefits of Aspirin in reducing the risk of certain cancers.
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Transcriptional regulation of the human thromboxane A2 receptor gene by Wilms' tumor (WT)1 and hypermethylated in cancer (HIC) 1 in prostate and breast cancers.
TL;DR: WT1 and HIC1, both tumor suppressors implicated in prostate and breast cancers, transcriptionally repress TPα expression and thereby provide a strong genetic basis for understanding the role of TXA2 in the progression of certain human cancers.
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Regulated Expression of the α Isoform of the Human Thromboxane A2 Receptor during Megakaryocyte Differentiation: A Coordinated Role for WT1, Egr1, and Sp1
TL;DR: Data establish that regulated WT1 followed by sequential Egr1 and Sp1 binding to elements within Prm1 mediate repression and subsequent induction of T Palpha during differentiation into the megakaryocytic phenotype, shedding significant insights into factors regulating TPalpha expression therein.
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Interaction of angio-associated migratory cell protein with the TPα and TPβ isoforms of the human thromboxane A2 receptor
TL;DR: In this paper, angio-associated migratory cell protein (AAMP) was identified as a novel interacting partner of both TPα and TPβ through an interaction dependent on common (residues 312-328) and unique (resinues 366-392 of TPβ) sequences within their carboxyl-terminal (C)-tail domains.
References
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MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data.
TL;DR: A set of tools for molecular biologists that allow generation of new matrix and detection of potential sequence matches by automatic searches with a library of pre-compiled matrices is presented in this article.
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Prostanoid Receptors: Structures, Properties, and Functions
TL;DR: An overview of the current status of research on the prostanoid receptors is given and domains and amino acid residues conferring the specificities of ligand binding and signal transduction are being clarified.
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Platelet activation in unstable coronary disease.
TL;DR: Data indicate that platelet activation occurs during spontaneous ischemia in patients with unstable angina, and the increment in prostacyclin biosynthesis during such episodes may be a compensatory response of vascular endothelium that limits the degree or effects of plateletactivation.
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A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development
Ramesh A. Shivdasani,Yuko Fujiwara,Yuko Fujiwara,Yuko Fujiwara,Michael A. McDevitt,Stuart H. Orkin +5 more
TL;DR: A critical role for GATA‐1 is revealed in megakaryocyte growth regulation and platelet biogenesis, and targeted mutation of cis‐elements can generate lineage‐specific knockout mice are illustrated.
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Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
Ramesh A. Shivdasani,Margery Rosenblatt,Dorothea Zucker-Franklin,Carl W. Jackson,Pamela Hunt,Chris J.M Saris,Stuart H. Orkin +6 more
TL;DR: The authors showed that NF-E2 −/− mice lack circulating platelets and die of hemorrhage; their megakaryocytes show no cytoplasmic platelet formation.