Journal ArticleDOI
Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness.
Thomas Bobbert,Jens Raila,Franziska Schwarz,Knut Mai,Andrea Henze,Andreas Pfeiffer,Florian J. Schweigert,Joachim Spranger +7 more
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TLDR
The data support that the transport complex of vitamin A is associated with the IMT, an established parameter of atherosclerosis.About:
This article is published in Atherosclerosis.The article was published on 2010-12-01. It has received 86 citations till now. The article focuses on the topics: Retinol binding protein 4 & Retinol binding protein.read more
Citations
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Journal ArticleDOI
RBP4: a controversial adipokine.
TL;DR: RBP4 is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome, but data are conflicting.
Journal ArticleDOI
Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update
TL;DR: The inflammatory, cardio-vascular and fibrogenic systems were those most frequently affected and they are one by one major actors in the high morbidity and mortality of CKD but also the mechanisms that have most frequently been studied.
Journal ArticleDOI
Retinol-Binding Protein 4 Induces Inflammation in Human Endothelial Cells by an NADPH Oxidase- and Nuclear Factor Kappa B-Dependent and Retinol-Independent Mechanism
TL;DR: It is revealed that RBP4 elevation can directly contribute to endothelial inflammation and therefore may play a causative role in the development or progression of vascular inflammation during cardiovascular disease and microvascular complications of diabetes.
Journal ArticleDOI
Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases.
TL;DR: Knowledge concerning the association of RBP4 with inflammation markers, oxidative stress, and CVDs as well as concerning the role of diet and antioxidants in decreasingRBP4 concentrations are discussed.
Journal ArticleDOI
Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study.
Qi Sun,Urban A. Kiernan,Ling Shi,David A. Phillips,Barbara B. Kahn,Frank B. Hu,JoAnn E. Manson,Christine M. Albert,Kathryn M. Rexrode +8 more
TL;DR: In this cohort of women, higher circulating full-length and total RBP4 levels were associated with increased risk of CHD in a time-dependent fashion.
References
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Journal ArticleDOI
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Qin Yang,Timothy E. Graham,Nimesh Mody,Frédéric Preitner,Odile D. Peroni,Janice M. Zabolotny,Ko Kotani,Loredana Quadro,Barbara B. Kahn +8 more
TL;DR: It is shown that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4-/- mice and RBP4 is an adipocyte-derived ‘signal’ that may contribute to the pathogenesis of type 2 diabetes.
Journal ArticleDOI
Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects
Timothy E. Graham,Qin Yang,Matthias Blüher,Ann Hammarstedt,Theodore P. Ciaraldi,Robert R. Henry,Christopher J. Wason,Andreas Oberbach,Per-Anders Jansson,Ulf Smith,Barbara B. Kahn +10 more
TL;DR: RBP4 is an adipocyte-secreted molecule that is elevated in the serum before the development of frank diabetes and appears to identify insulin resistance and associated cardiovascular risk factors in subjects with varied clinical presentations, providing a rationale for antidiabetic therapies aimed at lowering serum RBP4 levels.
Book ChapterDOI
Plasma retinol-binding protein: structure and interactions with retinol, retinoids, and transthyretin.
Giuseppe Zanotti,Rodolfo Berni +1 more
TL;DR: Overall, the available evidence indicates the existence of a high degree of complementarity between RBP and TTR, the contact areas of which are highly sensitive to conformational changes and amino acid replacements.
Journal ArticleDOI
Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly.
Erik Ingelsson,Johan Sundström,Håkan Melhus,Karl Michaëlsson,Christian Berne,Ramachandran S. Vasan,Ulf Risérus,Rune Blomhoff,Lars Lind,Johan Ärnlöv,Johan Ärnlöv +10 more
TL;DR: In elderly, RBP 4 concentrations were associated with MetS and its components in both sexes, and prior cerebrovascular disease in men, consistent with the hypothesis that circulating RBP4 could be a marker of metabolic complications and possibly also atherosclerosis and overt CVD.
Journal ArticleDOI
Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels
Andrea Henze,Simone K. Frey,Jens Raila,Martin Tepel,Alexandra Scholze,Andreas Pfeiffer,Martin O. Weickert,Joachim Spranger,Florian J. Schweigert +8 more
TL;DR: Existing human data showing elevated RBP4 levels in type 2 diabetic patients may be the result of moderate renal insufficiency rather than support for the suggestion thatRBP4 links obesity to type 2 diabetes.