Journal ArticleDOI
Relationship between drug dissolution and leaching of plasticizer for pellets coated with an aqueous Eudragit® S100:L100 dispersion
Hiroto Bando,James W. McGinity +1 more
TLDR
The plasticizer content in the film coating influenced the dissolution profile of theophylline from pellets coated with Eudragit S100:L100 (1:1) and a TEC level of approximately 30% in the films was the critical amount for initiating drug release during dissolution testing at pH 6.0.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2006-10-12. It has received 30 citations till now. The article focuses on the topics: Dissolution testing & TEC.read more
Citations
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Journal ArticleDOI
Materials for oral delivery of proteins and peptides
TL;DR: Physiological barriers to the oral delivery of protein-based therapies are discussed, along with the current translational landscape and state of the art of materials for oral protein delivery.
Journal ArticleDOI
Films from resistant starch-pectin dispersions intended for colonic drug delivery
TL;DR: Free films obtained by the solvent casting method from retrograded starch-pectin dispersions at different polymer proportions and concentrations with and without plasticizer indicated a more organized and crystalline structure of free films in relation to isolated polymers.
Journal ArticleDOI
Colonic treatments and targets: issues and opportunities.
TL;DR: The colon provides a plethora of therapeutic opportunities, and the emerging data on the levels of cell membrane transporters and metabolic enzymes along the gut could prove advantageous for systemic delivery via the colon, suggesting a potential for improved bioavailability of drug substrates at this site.
Journal ArticleDOI
Recent advances in colon drug delivery systems.
TL;DR: This work aims to bring together knowledge regarding the materials and processes used in the development of such pharmaceutical formulations, as well as to highlight recent advances in the field.
Journal ArticleDOI
Influence of plasticizer type and level on the properties of Eudragit® S100 matrix pellets prepared by hot-melt extrusion
Sandra U. Schilling,Hélène L. Lirola,Navnit Hargovindas Shah,A. Waseem Malick,James W. McGinity +4 more
TL;DR: Investigation of the influence of three plasticizers at two levels (10% or 20%) on the properties of hot-melt extruded Eudragit® S100 matrix pellets found the drug release in acidic medium was influenced by the aqueous solubility of the plasticizer.
References
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BookDOI
Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms
TL;DR: Aqueous polymeric coatings for pharmaceutical dosage forms , Aqueous Polymeric Coatings for Pharmaceutical dosage forms and more.
Journal ArticleDOI
A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers: I. Manipulation of drug release using Eudragit® L100-55 and Eudragit® S100 combinations
TL;DR: It is demonstrated that a combination of Eudragit L100-55 and EUDragit S100 can be successfully used from aqueous system to coat tablets for colon targeted delivery of drugs and the formulation can be adjusted to deliver drug at any other desirable site of the intestinal region of the GI tract on the basis of pH-variability.
Journal ArticleDOI
Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms.
TL;DR: The low permeability of a water-soluble drug, chlorpheniramine maleate, and the weak mechanical properties of Aquacoat films could suggest osmotic driven/rupturing effects as the release mechanisms from aquacoat-coated dosage forms.
Journal ArticleDOI
Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer.
TL;DR: Interestingly, drug release strongly depended on the type of plasticizer, and the hydrophilicity of the plasticizer significantly affected the water uptake behavior of the film coatings and, hence, changes in the coatings' toughness and drug permeability.