Journal ArticleDOI
Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension: Results from the Global SYMPLICITY Registry
Dominik Linz,Giuseppe Mancia,Felix Mahfoud,Krzysztof Narkiewicz,Luis M. Ruilope,Markus P. Schlaich,Ingrid Kindermann,Roland E. Schmieder,Sebastian Ewen,Bryan Williams,Michael Böhm +10 more
TLDR
This analysis of patients with and without OSA evaluated the blood pressure-lowering effect of sympathetic modulation by renal denervation (RDN) in a real-world setting, and found that RDN resulted in significant BP reductions at 6 months in hypertensive patients with a history of hypertension and regardless of continuous positive airway pressure usage in OSA patients.Abstract:
Background:Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system This analysis of patients with andread more
Citations
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Renal Denervation in Resistant Hypertension and Obstructive Sleep Apnea: Randomized Proof-of-Concept Phase II Trial.
Ewa Warchoł-Celińska,Aleksander Prejbisz,Jacek Kadziela,Elżbieta Florczak,Magdalena Januszewicz,Ilona Michałowska,Piotr Dobrowolski,Marek Kabat,P. Sliwinski,Anna Klisiewicz,Roman Topor-Madry,Krzysztof Narkiewicz,Virend K. Somers,Paul A. Sobotka,Adam Witkowski,Andrzej Januszewicz +15 more
TL;DR: In a randomized controlled trial, RDN lowered both office and ambulatory BP in patients with resistant hypertension and OSA and was accompanied by improvement of the clinical severity of OSA.
Journal ArticleDOI
Atrial fibrillation in obstructive sleep apnea: Neural mechanisms and emerging therapies.
Bing Huang,Huafen Liu,Benjamin J. Scherlag,Lihua Sun,Shifeng Xing,Jie Xu,Mei Luo,Yankai Guo,Guiqiu Cao,Hong Jiang +9 more
TL;DR: The autonomic nervous system may be a promising therapeutic target for OSA and AF because it plays a crucial role in atrial autonomic, structural, and electrical remodeling, thus providing substrates for AF maintenance and recurrence.
Journal ArticleDOI
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease
Keiko Takahashi,Seiji Ueda,Takashi Kobayashi,Akira Nishiyama,Yoshihide Fujisawa,Takeshi Sugaya,Satomi Shiota,Kazuhisa Takahashi,Tomohito Gohda,Satoshi Horikoshi,Yusuke Suzuki +10 more
TL;DR: It is demonstrated that CIH-mediated renal sympathetic nerve activation is involved in increased systemic oxidative stress, endothelial dysfunction, and renin-angiotensin system activation, thereby contributing to the development of HT and CVD, thus could be an important therapeutic target in patients with SAS.
Journal ArticleDOI
2019 Consensus Statement of the Taiwan Hypertension Society and the Taiwan Society of Cardiology on Renal Denervation for the Management of Arterial Hypertension.
Tzung-Dau Wang,Ying Hsiang Lee,Shih Sheng Chang,Ying Chang Tung,Chih Fan Yeh,Yen-Hung Lin,Chien Ting Pan,Chien Yi Hsu,Chun Yao Huang,Cho-Kai Wu,Pei-Hsun Sung,Liang Ting Chiang,Yu-Chen Wang,Yu-Chen Wang,Wei-Chung Tsai,Ting-Tse Lin,Chia Pin Lin,Wen-Jone Chen,Juey-Jen Hwang +18 more
TL;DR: The Task Force considers RDN as a legitimate alternative antihypertensive strategy and recommends RDN should be performed in the context of registry and clinical studies and should not be performed routinely, without detailed evaluation of various causes of secondary hypertension and renal artery anatomy.
Journal ArticleDOI
Modulation of renal sympathetic innervation: recent insights beyond blood pressure control
Dominik Linz,Mathias Hohl,Adrian D. Elliott,Dennis H. Lau,Felix Mahfoud,Felix Mahfoud,Murray D. Esler,Prashanthan Sanders,Michael Böhm +8 more
TL;DR: The current literature on anti-arrhythmic effects of RDN is reviewed with the focus on atrial fibrillation and ventricular arrhythmias and new insights from preclinical and clinical mechanistic studies and possible clinical implications are discussed.
References
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Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate.
Andrew S. Levey,Josef Coresh,Tom Greene,Lesley A. Stevens,Yaping (Lucy) Zhang,Stephen Hendriksen,John W. Kusek,Frederick Van Lente +7 more
TL;DR: The MDRD Study equation has now been reexpressed for use with a standardized serum creatinine assay, allowing GFR estimates to be reported in clinical practice by using standardized serumcreatinine and overcoming this limitation to the current use of GFR estimating equations.
Journal ArticleDOI
Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares
TL;DR: Five patients with severe obstructive sleep apnoea were treated with continuous positive airway pressure (CPAP) applied via a comfortable nose mask through the nares, which provides a pneumatic splint for the nasopharyngeal airway and is a safe, simple treatment for the obstructiveSleep apNoea syndrome.
Journal ArticleDOI
A Controlled Trial of Renal Denervation for Resistant Hypertension
Deepak L. Bhatt,David E. Kandzari,John M. Flack,Barry T. Katzen,Martin B. Leon,Minglei Liu,Laura Mauri,Manuela Negoita,Sidney Cohen,Suzanne Oparil,Krishna J. Rocha-Singh,Raymond R. Townsend,George L. Bakris,Abstr Act +13 more
TL;DR: This blinded trial did not show a significant reduction of systolic blood pressure in patients with resistant hypertension 6 months after renal-artery denervation as compared with a sham control.
Journal ArticleDOI
Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing.
Virend K. Somers,David P. White,Raouf S. Amin,William T. Abraham,Fernando Ferreira Costa,Antonio Culebras,Stephen R. Daniels,John S. Floras,Carl E. Hunt,Lyle J. Olson,Thomas G. Pickering,Richard O. Russell,Mary Woo,Terry Young +13 more
Journal ArticleDOI
Sleep Apnea and Cardiovascular Disease An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
Virend K. Somers,David P. White,Raouf S. Amin,William T. Abraham,Fernando Ferreira Costa,Antonio Culebras,Stephen R. Daniels,John S. Floras,Carl E. Hunt,Lyle J. Olson,Thomas G. Pickering,Richard O. Russell,Mary Woo,Terry Young +13 more
TL;DR: This first American Heart Association/American College of Cardiology Scientific Statement on Sleep Apnea and Cardiovascular Disease seeks to highlight concepts and evidence important to understanding the interactions between sleep apnea and cardiovascular disease, with particular attention to more recent advances in patient-oriented research.