Journal ArticleDOI
Reproductive factors and risk of uterine fibroids.
TLDR
Compared with nulliparae, parous women had a relative risk of fibroids of 0.5 [95% confidence interval (CI) = 0.4-0.6], and the risk declined with number of births, while the risk decreased withNumber of induced abortions.Abstract:
We analyzed the relation between reproductive history and risk of uterine fibroids using data from a case-control study. Cases were 621 women with histologically confirmed diagnosis of uterine fibroids. Controls were 1,051 non-hysterectomized patients. Compared with nulliparae, parous women had a relative risk (RR) of fibroids of 0.5 [95% confidence interval (CI) = 0.4-0.6], and the risk declined with number of births. The risk of fibroids also decreased with number of induced abortions (RR = 0.8 and 0.6 for women reporting one or two or more abortions, respectively). A total of 24 cases (3.9%) and 19 controls (1.8%) reported a history of infertility (RR = 2.0; 95% CI = 1.1-3.7).read more
Citations
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Journal ArticleDOI
Etiology, symptomatology, and diagnosis of uterine myomas.
TL;DR: Although uterine myomas presently are not well understood, many advances have been made in the understanding of the hormonal factors, genetic factors, growth factors, and molecular biology of these benign tumors.
Journal ArticleDOI
Etiology and pathogenesis of uterine leiomyomas: a review.
TL;DR: Growth factors with mitogenic activity, such as transforming growth factor- (subscript)3(/subscript), basic fibroblast growth factor, epidermal growth factors, and insulin-like growth factors-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion.
Journal ArticleDOI
Incidence, aetiology and epidemiology of uterine fibroids.
TL;DR: Black race, heredity, nulliparity, obesity, polycystic ovary syndrome, diabetes and hypertension are associated with increased risk of fibroids, and there is emerging evidence that familial predisposition to fibroid is associated with a distinct pattern of clinical and molecular features compared with fibroIDS in families without this prevalence.
Journal ArticleDOI
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing.
D. Andrew Crain,Sarah J. Janssen,Thea M. Edwards,Jerrold J. Heindel,Shuk-Mei Ho,Patricia A. Hunt,Taisen Iguchi,Anders Juul,John A. McLachlan,Jackie M. Schwartz,N E Skakkebaek,Ana M. Soto,Shanna H. Swan,Cheryl L. Walker,Teresa K. Woodruff,Tracey J. Woodruff,Linda C. Giudice,Louis J. Guillette +17 more
TL;DR: This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved and illustrates the sensitivity of early life-stage exposures.
Journal ArticleDOI
Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women
TL;DR: Uterine fibroid is a common concern in women at fertile age causing multiple bleeding and pain symptoms which can have a negative impact on different aspects in women's life.
References
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Journal ArticleDOI
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
Nathan Mantel,William Haenszel +1 more
TL;DR: In this paper, the role and limitations of retrospective investigations of factors possibly associated with the occurrence of a disease are discussed and their relationship to forward-type studies emphasized, and examples of situations in which misleading associations could arise through the use of inappropriate control groups are presented.
Journal ArticleDOI
Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel-Haenszel Procedure
TL;DR: In this article, a method for analyzing multiple 2×2 contingency tables arising in retrospective studies of disease is extended in application and form, which includes comparisons of age-adjusted death rates, life-table analyses, comparisons of two sets of quantal dosage response data, and miscellaneous laboratory applications as appropriate.
Journal ArticleDOI
Uterine leiomyomata: etiology, symptomatology, and management
TL;DR: No studies have yet demonstrated that women on oral pills are at increased risk for growth of these tumors, and low-dose contraceptives should not be contraindicated in patients with leiomyomata if they desire to use this form of contraceptive.
Journal ArticleDOI
Risk factors for uterine fibroids: reduced risk associated with oral contraceptives.
TL;DR: Investigation of risk factors for pathologically confirmed uterine leiomyomas (fibroids) in the Oxford Family Planning Association study showed that reproductive experiences were closely linked to development of fibroids, suggesting that the underlying risk factor is "unopposed" oestrogen.
Journal ArticleDOI
Epidemiologic characteristics of women with uterine fibroids: a case-control study.
TL;DR: Women with fibroids tended to have an earlier age at menarche and at the last birth, to be more educated, and to use intrauterine devices and oral contraceptives more frequently, although these findings were not statistically significant.