Journal ArticleDOI
Resistance to fatigue of single muscle fibres from Xenopus related to succinate dehydrogenase and myofibrillar ATPase activities.
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TLDR
It was found that resistance to fatigue correlates with succinate dehydrogenase activity and with myofibrillar ATPase activity, and that muscular fatigue is closely related to cellular energetics.Abstract:
This report describes how the resistance to fatigue of a muscle fibre relates to the fibre's most important ATP-producing and ATP-consuming reactions. Twelve intact single muscle fibres were dissected from lumbrical muscles of Xenopus laevis. Their resistance to fatigue induced by repeated tetanic stimulation was determined, as well as their succinate dehydrogenase activity and calcium-stimulated myofibrillar ATPase activity. The enzyme activities were determined by means of quantitative histochemistry. It was found that resistance to fatigue correlates with succinate dehydrogenase activity (r = 0.83) and with myofibrillar ATPase activity (r = -0.74). The highest correlation was found between resistance to fatigue and the ratio of succinate dehydrogenase to myofibrillar ATPase activity (r = 0.93). It is concluded that muscular fatigue is closely related to cellular energetics.read more
Citations
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Muscle cell function during prolonged activity: cellular mechanisms of fatigue
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Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue
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Neuromuscular fatigue in healthy muscle: underlying factors and adaptation mechanisms.
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References
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Chemical energetics of slow- and fast-twitch muscles of the mouse.
TL;DR: For both the slow-twitch soleus and the fast-twitch EDL and for all tetanus durations (up to 15 s), the extent of the initial chemical change was identical with the amount of recovery chemical resynthesis, showing that a biochemical energy balance existed in these muscles.
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Intracellular calcium and tension during fatigue in isolated single muscle fibres from Xenopus laevis.
TL;DR: The reduced [Ca2+]i during tetani at the end of fatiguing stimulation (when tension was reduced to approximately 50%) could explain all of the reduction in tension.
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Types of Muscle Fibres in Toad Skeletal Muscle
Jan Lännergren,Richard S. Smith +1 more
TL;DR: An attempt has been made to define the types of muscle fibres present in the iliofibularis muscle of Xenopus laevis and the findings indicated a relationship between the histochemical and functional properties of the Muscle fibres.
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Maximum velocity of shortening related to myosin isoform composition in frog skeletal muscle fibres.
TL;DR: The results support the view that the variability in shortening velocity and myofibrillar ATPase activity that exists among twitch fibres in frog skeletal muscle is based on differences in myosin heavy‐chain composition.
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Force and membrane potential during and after fatiguing, continuous high-frequency stimulation of single Xenopus muscle fibres.
Jan Lännergren,Håkan Westerblad +1 more
TL;DR: It is concluded that mechanical fatigue is unlikely to be due to 'fatigue' of surface action potentials per se; a more likely mechanism would be impaired t-tubule function, associated with membrane depolarization (Em becoming more positive) and possibly compounded by ionic changes of the t- Tubule fluid.