Book ChapterDOI
Retinoids and Chemoprevention of Cancer
Michael B. Sporn,Dianne L. Newton +1 more
- pp 71-100
TLDR
The role of retinol and its esters in determining normal epithelial cell differentiation has been known for over 50 years since the classical studies of Wolbach and Howe (1925) who observed the differentiated cells of various specialized epithelia throughout the body were replaced by squamous, keratinizing cells during retinoid* deficiency.Abstract:
The role of retinol and its esters in determining normal epithelial cell differentiation has been known for over 50 years since the classical studies of Wolbach and Howe (1925) who observed the differentiated cells of various specialized epithelia throughout the body were replaced by squamous, keratinizing cells during retinoid* deficiency.read more
Citations
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Journal Article
Chemoprevention of Cancer
TL;DR: This Perspective deals with the areas in cancer control that this field addresses, the promise that it holds, and the problems that must be solved in order to realize its goals.
Journal Article
Role of retinoids in differentiation and carcinogenesis.
TL;DR: It has been known for more than 50 years that retinoids, the family of molecules comprising both the natural and synthetic analogues of retinol, are potent agents for control of both cellular differentiation and cellular proliferation as discussed by the authors.
Journal ArticleDOI
13-cis-retinoic acid in the treatment of oral leukoplakia.
Waun Ki Hong,J Endicott,Loretta M. Itri,W Doos,J G Batsakis,R Bell,S Fofonoff,Robert M. Byers,Edward N. Atkinson,C Vaughan +9 more
TL;DR: It is concluded that 13-cis-retinoic acid, even in short-term use, appears to be an effective treatment for oral leukoplakia and has an acceptable level of toxicity.
Journal ArticleDOI
Vitamin A and retinoids in health and disease.
TL;DR: NIGHT blindness was recognized as a disease entity in ancient Egypt and literature dating from ancient times to the early 20th century contains comments that appear to indicate recognition of the existence of a dietary substance necessary for night vision.
Journal ArticleDOI
Dietary habits and lung cancer risk.
TL;DR: It is found that the apparent protection afforded by higher intakes of vitamin A or its provitamins was particularly strong for lung cancer appearing as squamous‐cell carcinoma and among those with higher alcohol intakes.
References
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Journal ArticleDOI
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.
TL;DR: This study suggests that retinoids could provide a therapeutic tool in the treatment of acute myeloid leukemia, and indicates thatretinoids, in addition to their well-characterized involvement in epithelial cell differentiation, may also be involved in the differentiation of certain hematopoietic cells.
Journal ArticleDOI
Tissue changes following deprivation of fat-soluble a vitamin
S. Burt Wolbach,Percy R. Howe +1 more
TL;DR: The specific tissue changes which follow the deprivation of fat-soluble vitamin A in albino white rats and in the human concerns epithelial tissues are described and it is concluded that the deficiency results in loss of specific (chemical) functions of the epitheliums concerned, while the power of growth becomes augmented.
Journal ArticleDOI
Growth factors from murine sarcoma virus-transformed cells.
J E De Larco,George J. Todaro +1 more
TL;DR: The sarcoma growth factors are a new class of polypeptide tropic factors that confer on fibroblasts in vitro properties associated with the transformed phenotype that are heat-stable, trypsin-sensitive, and active in nanogram quantities when tested for growth stimulation of untransformed rat and mouse fibro Blasts.
Journal ArticleDOI
The induction of differentiation in teratocarcinoma stem cells by retinoic acid
Sidney Strickland,Vijak Mahdavi +1 more
TL;DR: Using one embryonal carcinoma cell line, F9, it is found that retinoic acid at concentrations as low as 10(-9) M induces multiple phenotypic changes in the cultures in vitro, which are consistent with the proposition that retinosic acid induces differentiation of embryonal cancer cells into endoderm.