Journal ArticleDOI
Rhodium-catalyzed intramolecular [4 + 2] cycloadditions of alkynyl halides.
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TLDR
Cationic rhodium(I)-catalyzed intramolecular [4 + 2] cycloadditions of diene-tethered alkynyl halides were found to occur in good yields and could be transformed into a variety of products that are difficult or impossible to obtain via directcycloaddition.About:
This article is published in Organic Letters.The article was published on 2005-11-22. It has received 45 citations till now. The article focuses on the topics: Cycloaddition & Intramolecular force.read more
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Patent
Nouveaux inhibiteurs macrocycliques de réplication du virus de l'hépatite C
Andrews Steven W,Leonid Beigelman,Lawrence M. Blatt,Kevin Ronald Condroski,Jiang Yutong,Kaus Robert,Kennedy April L,Timothy Kercher,Jyanwei Liu,Michael Lyon,Pierre Martin,Lin Pan,Schumacher Andreas,Scott D. Seiwert,Bin Wang +14 more
TL;DR: In this paper, the modes de realisation portent sur des composes de la formule generale I ainsi que des compositions, and compris des compositions pharmaceutiques comprenant un compose objet de l'invention.
Patent
Inhibiteurs macrocycliques innovants de la réplication du virus de l'hépatite c
Lawrence M. Blatt,Lin Pan,Scott D. Seiwert,Andrews Steven W,Pierre Martin,Schumacher Andreas,Leonid Beigelman,Jyanwei Liu,Kevin Ronald Condroski,Jiang Yutong,Kaus Robert,Kennedy April L,Timothy Kercher,Michael Lyon,Bin Wang +14 more
TL;DR: The modes de realisation de la presente invention concernent des composes de formule generale (I), ainsi que des compositions, and compris des compositions pharmaceutiques, comprenant un compose sujet de l'invention as mentioned in this paper.
Journal ArticleDOI
Expedient Synthesis of Dihaloalkenynes via Pd-Catalyzed Haloalkynylation Reaction.
Xiaoliang Ji,Xin Peng,Huanliang Hong,Yanghao Xu,Jinli Nie,Lu Chen,Zongwen Mo,Yibiao Li,Huanfeng Jiang +8 more
TL;DR: In this article , the PdII-catalyzed construction of functionalized dihaloalkennes from haloalkynes via a self-halo-alkynylation reaction, without specialized ligands or oxidizing additives, is reported.
Patent
Makrocyclische Inhibitoren der Replikation des Hepatitis-C-Virus
Scott D. Seiwert,Lawrence M. Blatt,Andrews Steven W,Pierre Martin,Schumacher Andreas,Bradley R. Barnett,C. Todd Eary,Kaus Robert,Timothy Kercher,Weidong Liu,Michael Lyon,Paul J. Nichols,Bin Wang,Tarek Sammakia,Kennedy April L,Jiang Yutong +15 more
References
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Journal ArticleDOI
Transition Metal-Mediated Cycloaddition Reactions
TL;DR: The phytochemical remains of the seven-membered ring formation are still under investigation, but it is clear that the polymethine content of the ring is lower than previously thought, suggesting that it is more likely to be a mixture of 22π and 32σ.
Journal ArticleDOI
Copper sulfate-pentahydrate-1,10-phenanthroline catalyzed amidations of alkynyl bromides. Synthesis of heteroaromatic amine substituted ynamides.
TL;DR: A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO(4).5H(2)O and 1,10-phenanthroline is described here and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted ynamide.
Journal ArticleDOI
Ultrahigh-Quality NOE Spectra
Journal ArticleDOI
Coupling Reactions of Alkynylsilanes Mediated by a Cu(I) Salt: Novel Syntheses of Conjugate Diynes and Disubstituted Ethynes
Yasushi Nishihara,Kazutaka Ikegashira,Kazunori Hirabayashi,Jun Ichi Ando,Atsunori Mori,Tamejiro Hiyama +5 more
TL;DR: The cross-coupling reaction is applied to a one-pot synthesis of the corresponding unsymmetrical diarylethynes from (trimethylsilyl)ethyne via sequential Sonogashira-Hagihara and the present cross-Coupling reactions using two different aryl triflates.
Journal ArticleDOI
A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides.
Michael O. Frederick,Jason A. Mulder,Michael R. Tracey,Richard P. Hsung,Jian Huang,Kimberly C. M. Kurtz,Lichun Shen,Christopher J. Douglas +7 more
TL;DR: A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides, which should have a significant impact on the future development of synthetic methodologies employing ynamide.
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Paul A. Wender,Thomas E. Jenkins +1 more