Journal ArticleDOI
Risk Factors and Prognostic Factors of Local Recurrence after Radiofrequency Ablation of Hepatocellular Carcinoma
Vincent W. T. Lam,Kelvin K. Ng,Kenneth S. H. Chok,Tan To Cheung,Jimmy H. F. Yuen,Helen Tung,Wai-Kuen Tso,Sheung Tat Fan,Ronnie T.P. Poon +8 more
TLDR
This study demonstrated that tumor size > 2.5 cm was the main risk factor for local recurrence after RFA of hepatocellular carcinoma, and suggested that additional aggressive treatment ofLocal recurrence aimed at complete tumor response improves overall survival of patients.Abstract:
Background Local recurrence rates after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from 2% to 36% in the literature. Limited data were available about the prognostic significance of local recurrence. Study Design Between April 2001 and March 2006, 273 patients with 357 hepatocellular carcinoma nodules underwent RFA, with radiologically complete tumor ablation after a single session of RFA. The risk factors of local recurrence and its impact on overall survival of patients were analyzed. Results With a median followup period of 24 months, local recurrence occurred in 35 patients (12.8%). By multivariate analysis, tumor size > 2.5 cm was the only independent risk factor for local recurrence. There was no notable difference in overall survival between patients with and without local recurrence. By multivariate analysis, local recurrence more than 12 months after RFA and complete response after additional treatment of local recurrence were associated with better overall survival in patients with local recurrence. Conclusions This study demonstrated that tumor size > 2.5 cm was the main risk factor for local recurrence after RFA of hepatocellular carcinoma. Our data suggested that additional aggressive treatment of local recurrence aimed at complete tumor response improves overall survival of patients. Late local recurrence was also associated with better prognosis, suggesting different tumor biology between early and late local recurrent tumors after RFA.read more
Citations
More filters
Journal ArticleDOI
Radiofrequency ablation of hepatocellular carcinoma: long-term results and prognostic factors in 235 Western patients with cirrhosis.
Gisèle N'Kontchou,Amel Mahamoudi,Mounir Aout,Nathalie Ganne-Carrié,Véronique Grando,Emmanuelle Coderc,Eric Vicaut,Jean Claude Trinchet,Nicolas Sellier,Michel Beaugrand,Olivier Seror +10 more
TL;DR: RFA is a safe and effective first‐line treatment of HCC up to 5 cm in diameter, especially for patients with a single tumor, a low serum AFP level, and well‐preserved liver function.
Journal ArticleDOI
Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma: Analysis of prognostic factors
Young-sun Kim,Hyo Keun Lim,Hyunchul Rhim,Min Woo Lee,Dongil Choi,Won Jae Lee,Seung Woon Paik,Kwang Cheol Koh,Joon Hyeok Lee,Moon Seok Choi,Geum-Youn Gwak,Byung Chul Yoo +11 more
TL;DR: Ten-year survival outcomes after percutaneous radiofrequency ablation as a first-line therapy of hepatocellular carcinoma were excellent despite frequent tumor recurrences, and overall survival was influenced by age, Child-Pugh class, antiviral therapy, or extrahepatic recurrence.
Journal ArticleDOI
Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma
Josep M. Llovet,Josep M. Llovet,Thierry de Baere,Thierry de Baere,Laura Kulik,Philipp K. Haber,Tim F. Greten,Tim Meyer,Tim Meyer,Riccardo Lencioni +9 more
TL;DR: In this paper, the authors analyse data from randomized and uncontrolled studies reported with ablative and locoregional techniques and examine the expected effects of combinations with systemic treatments, and discuss trial design and benchmarks to be used as a reference for future investigations in a promising new era for HCC treatment.
Journal ArticleDOI
Percutaneous treatment of hepatocellular carcinoma: State of the art and innovations.
Jean-Charles Nault,Jean-Charles Nault,Olivier Sutter,Pierre Nahon,Pierre Nahon,Nathalie Ganne-Carrié,Nathalie Ganne-Carrié,Olivier Seror,Olivier Seror +8 more
TL;DR: Percutaneous ablation could also be used as a bridge to liver transplantation or in a sequence of upfront percutaneous treatment, followed by transplantation if the patient relapses, and several innovations in ablation methods may help to efficiently treat early HCC.
Journal ArticleDOI
Radiofrequency Ablation of Hepatocellular Carcinoma as First-Line Treatment: Long-term Results and Prognostic Factors in 162 Patients with Cirrhosis
Dong Ho Lee,Jeong Min Lee,Jae Young Lee,Se Hyung Kim,Jung Hwan Yoon,Yoon Jun Kim,Joon Koo Han,Byung Ihn Choi +7 more
TL;DR: RFA is a safe and effective first-line treatment for early-stage HCC, with a 5-year survival rate of 67.9%.
References
More filters
Journal ArticleDOI
Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial.
Josep M. Llovet,Maria Isabel Real,Xavier Montaña,Ramon Planas,Susana Coll,John J. Aponte,Carmen Ayuso,Margarita Sala,Jordi Muchart,Ricard Solà,Joan Rodés,Jordi Bruix +11 more
TL;DR: Chemoembolisation improved survival of stringently selected patients with unresectable hepatocellular carcinoma and was associated with a significantly lower rate of portal-vein invasion than conservative treatment.
Journal ArticleDOI
Rising incidence of hepatocellular carcinoma in the United States.
TL;DR: The incidence of hepatocellular carcinoma increased significantly among younger persons (40 to 60 years old) during the period from 1991 to 1995 as compared with earlier periods, and the age-specific incidence of this cancer has progressively shifted toward younger people.
Journal ArticleDOI
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma.
Chung Mau Lo,Henry Ngan,Wai Kuen Tso,Chi-Leung Liu,Chi Ming Lam,Ronnie T.P. Poon,Sheung Tat Fan,John Wong +7 more
TL;DR: In Asian patients with unresectable hepatocellular carcinoma, transarterial Lipiodol chemoembolization significantly improves survival and is an effective form of treatment.
Journal ArticleDOI
A Prospective Randomized Trial Comparing Percutaneous Local Ablative Therapy and Partial Hepatectomy for Small Hepatocellular Carcinoma
Minshan Chen,Jin Qing Li,Yun Zheng,Rong Ping Guo,Hui Hong Liang,Ya Qi Zhang,Xiaojun Lin,Wan Y. Lau +7 more
TL;DR: PLAT was as effective as surgical resection in the treatment of solitary and small HCC and had the advantage over surgical resections in being less invasive.
Journal ArticleDOI
Small Hepatocellular Carcinoma: Treatment with Radio-frequency Ablation versus Ethanol Injection
Tito Livraghi,S. Nahum Goldberg,Sergio Lazzaroni,Franca Meloni,Luigi Solbiati,G. Scott Gazelle +5 more
TL;DR: RF ablation results in a higher rate of complete necrosis and requires fewer treatment sessions than percutaneous ethanol injection, however, the complication rate is higher with RF ablation than with percutaneously ethanol injection.