Journal ArticleDOI
Role of association of OmpK35 and OmpK36 alteration and blaESBL and/or blaAmpC genes in conferring carbapenem resistance among non-carbapenemase-producing Klebsiella pneumoniae.
Zaineb Hamzaoui,Zaineb Hamzaoui,Alain A. Ocampo-Sosa,Marta Fernandez Martinez,Sarrah Landolsi,Sana Ferjani,Elaa Maamar,Mabrouka Saidani,Amine Slim,Luis Martínez-Martínez,Ilhem Boutiba-Ben Boubaker +10 more
TLDR
Loss or deficiency of OMPs, coupled with ESBL and/or AmpC production, plays an important role in conferring carbapenem resistance in K. pneumoniae.About:
This article is published in International Journal of Antimicrobial Agents.The article was published on 2018-12-01. It has received 71 citations till now. The article focuses on the topics: Klebsiella pneumoniae & Ertapenem.read more
Citations
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Epidemiology of β-Lactamase-Producing Pathogens.
Karen Bush,Patricia A. Bradford +1 more
TL;DR: As selective pressure from β-lactam use continues, multiple β-Lactamases per organism are increasingly common, including pathogens carrying three different carbapenemase genes, warranting close attention to increased infection control measures and stewardship of the β- lactam-containing drugs in an effort to control selection of even more deleterious pathogens.
Journal ArticleDOI
The Current Burden of Carbapenemases: Review of Significant Properties and Dissemination among Gram-Negative Bacteria.
TL;DR: The aims of the current review are to define and categorize the different families of carbapenemases, and to overview the main lines of their spread across different bacterial groups.
Journal ArticleDOI
Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for the Rapid Detection of Antimicrobial Resistance Mechanisms and Beyond.
Marina Oviaño,Germán Bou +1 more
TL;DR: This review provides an expert guide for MALDI-TOF MS users to new approaches in the field of antimicrobial resistance detection, especially possible applications as a routine diagnostic tool in microbiology laboratories.
Journal ArticleDOI
Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children.
TL;DR: A framework for antibiotic treatment of CRE infections in children is provided, highlighting relevant microbiologic considerations and summarizing available data related to the evaluation of FDA-approved antibiotics (as of September 2019) with CRE activity, including carbapenems, ceftazidime-avibactam, meropenem-vaborbactam and plazomicin.
Journal ArticleDOI
Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current Reports.
Masego Mmatli,Nontombi Marylucy Mbelle,Nontuthuko Excellent Maningi,Nontuthuko Excellent Maningi,John Osei Sekyere +4 more
TL;DR: Carapenem and polymyxin resistance is mediated by a diverse range of genetic and transcriptional mechanisms that are easily activated in an inducing environment and the molecular understanding of these emerging mechanisms can aid in developing new therapeutics for multidrug-resistant Enterobacteriaceae isolates.
References
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Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more
TL;DR: A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control and the Centers for Disease Control and Prevention, to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp.
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Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing.
Fred C. Tenover,Robert D. Arbeit,Richard V. Goering,P. A. Mickelsen,Barbara E Murray,D. H. Persing,B. Swaminathan +6 more
TL;DR: This research presents a novel, scalable and scalable approach that allows for real-time assessment of the severity of the infection and its impact on patients’ health.
Journal ArticleDOI
Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae
TL;DR: The development of a useful method composed of a set of six multiplex PCRs and one simplex PCR for the rapid screening of the most frequently encountered beta-lactamases is reported.
Journal ArticleDOI
Carboxy-terminal phenylalanine is essential for the correct assembly of a bacterial outer membrane protein.
TL;DR: Site-directed mutagenesis was applied to study the role of the C-terminal Phe in PhoE protein assembly and it appears that both the hydrophobicity and the aromatic nature of Phe are of importance.
Journal ArticleDOI
Mechanisms of Resistance in Multiple-Antibiotic-Resistant Escherichia coli Strains of Human, Animal, and Food Origins
Yolanda Sáenz,Laura Briñas,Elena Domínguez,Joaquim Ruiz,Myriam Zarazaga,Jordi Vila,Carmen Torres +6 more
TL;DR: Seventeen multiple-antibiotic-resistant nonpathogenic Escherichia coli strains of human, animal, and food origins showed a wide variety of antibiotic resistance genes, many of them carried by class 1 and class 2 integrons.