Journal ArticleDOI
Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective
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This article is published in Chemical Research in Toxicology.The article was published on 1998-09-01. It has received 274 citations till now.read more
Citations
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Book ChapterDOI
Drug-induced liver injury.
Michael P. Holt,Changqing Ju +1 more
TL;DR: It is hoped that this chapter will shed light on the major problems associated with DILI in regards to the pharmaceutical industry, drug regulatory agencies, physicians and pharmacists, and patients.
Journal ArticleDOI
Delayed Drug Hypersensitivity Reactions
TL;DR: This review presents newer concepts of the role of T cells in drug hypersensitivity, which evolved from the study of drug-specific T Cells in various drug-induced hypersensitivity diseases.
Journal ArticleDOI
Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
TL;DR: This paper serves to provide one pragmatic approach to addressing the issue of bioactivation from an industry viewpoint based on protocols adopted by Merck Research Laboratories.
Journal ArticleDOI
Metabolism of fluorine-containing drugs.
TL;DR: The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.
Journal ArticleDOI
The lymphocyte transformation test in the diagnosis of drug hypersensitivity.
Werner J. Pichler,J. Tilch +1 more
TL;DR: The lymphocyte transformation test (LTT) measures the proliferation of T cells to a drug in vitro– from which one concludes to a previous in vivo reaction due to a sensitization, and the finding that drugs can directly interact with the T‐cell receptor, without previous metabolism or need to bind to proteins.
References
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Journal ArticleDOI
Tolerance, danger, and the extended family.
TL;DR: The possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues is discussed.
Journal ArticleDOI
Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention
David W. Bates,D J Cullen,Nan M. Laird,Laura A. Petersen,Small Sd,Servi D,G Laffel,Bobbie Jean Sweitzer,Shea Bf,Hallisey R +9 more
TL;DR: Adverse drug events were common and often preventable; serious ADEs were more likely to be preventable and prevention strategies should target both stages of the drug delivery process.
Journal ArticleDOI
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.
John Savill,Andrew H. Wyllie,Janet E. Henson,Mark Walport,Peter M. Henson,Christopher Haslett +5 more
TL;DR: Changes in the senescent neutrophil that are associated with their recognition by macrophages are the subject of this investigation, and these processes may represent a mechanism for the removal of neutrophils during inflammation that also serves to limit the degree of tissue injury.
Journal ArticleDOI
Severe Adverse Cutaneous Reactions to Drugs
TL;DR: Adverse cutaneous reactions to drugs are frequent, affecting 2 to 3 percent of hospitalized patients, and prompt withdrawal of the offending drug is often the most important action to minimize morbidity.
Journal ArticleDOI
Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.
Ch. Huber,J R Batchelor,Dietmar Fuchs,Arno Hausen,A. Lang,Dietger Niederwieser,Gilbert Reibnegger,P. Swetly,Jakob Troppmair,H. Wachter +9 more
TL;DR: It is demonstrated that macrophages stimulated with supernatant from activated T cells release large amounts of neopterin into culture supernatants, indicating that a metabolic pathway so far exclusively known in context with the generation of an essential cofactor of neurotransmitter-synthesis during immune responses is also activated in M phi under stringent control by immune IFN-like lymphokines.
Related Papers (5)
Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies
Studies on the sensitization of animals with simple chemical compounds
Karl Landsteiner,John Jacobs +1 more