Journal ArticleDOI
Severe Adverse Cutaneous Reactions to Drugs
TLDR
Adverse cutaneous reactions to drugs are frequent, affecting 2 to 3 percent of hospitalized patients, and prompt withdrawal of the offending drug is often the most important action to minimize morbidity.Abstract:
Although the rate of acute severe adverse cutaneous reactions to medications is low, these reactions can affect anyone who takes medications and can result in death or disability1. Even a small number of cases associated with a particular drug may alter the recommendations for its use2–4. Prompt differentiation of severe adverse cutaneous reactions from less serious skin disorders may be difficult. Rapid recognition of severe reactions is essential. Prompt withdrawal of the offending drug is often the most important action to minimize morbidity. Adverse cutaneous reactions to drugs are frequent, affecting 2 to 3 percent of hospitalized . . .read more
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Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis
Jean-Claude Roujeau,Judith P. Kelly,Luigi Naldi,B. Rzany,Robert S. Stern,Theresa E. Anderson,Ariane Auquier,Sylvie Bastuji-Garin,Osvaldo Correia,F. Locati +9 more
TL;DR: Risks were increased for trimethoprim–sulfamethoxazole and other sulfonamide antibiotics, chlormezanone, quinolones, and aminopenicillins among drugs usually used for short periods.
Journal ArticleDOI
Adverse effects of antiretroviral therapy
TL;DR: This review focuses on the pathogenesis, clinical features, and management of the principal toxicities of the 15 licensed antiretroviral drugs, including mitochondrial toxicity, hypersensitivity, and lipodystrophy, as well as more drug-specific adverse effects and special clinical settings.
Journal ArticleDOI
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Isabelle Viard,Philippe Wehrli,Roberto Bullani,Pascal Schneider,Nils Holler,Denis Salomon,Thomas Hunziker,Jean-Hilaire Saurat,Jürg Tschopp,Lars E. French +9 more
TL;DR: Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro and indicated that IVIG may be an effective treatment for toxic epidermal necrolysis of TEN.
Journal ArticleDOI
SCORTEN: A Severity-of-Illness Score for Toxic Epidermal Necrolysis
Sylvie Bastuji-Garin,Nathalie Fouchard,M Bertocchi,Jean-Claude Roujeau,Jean Revuz,Pierre Wolkenstein +5 more
TL;DR: It is demonstrated that the risk of death of toxic epidermal necrolysis patients can be accurately predicted by the toxic epidescent severity-of-illness score, and the Simplified Acute Physiology Score and burn score appear to be less adequate.
Journal ArticleDOI
Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS).
TL;DR: The term of DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) is proposed, to decrease the ambiguity of the denomination of hypersensitivity syndrome.
References
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Journal ArticleDOI
The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II
Lucian L. Leape,Troyen A. Brennan,Nan M. Laird,Ann G. Lawthers,A R Localio,B A Barnes,Liesi E. Hebert,Joseph P. Newhouse,Paul C. Weiler,Howard H. Hiatt +9 more
TL;DR: The high proportion that are due to management errors suggests that many others are potentially preventable now, and reducing the incidence of these events will require identifying their causes and developing methods to prevent error or reduce its effects.
Journal ArticleDOI
Wegener granulomatosis : an analysis of 158 patients
Gary S. Hoffman,Gail S. Kerr,Randi Y. Leavitt,Claire W. Hallahan,Robert S. Lebovics,William D. Travis,Menachem Rottem,Anthony S. Fauci +7 more
TL;DR: The course of Wegener granulomatosis has been dramatically improved by daily treatment with cyclophosphamide and glucocorticoids, and has led to increasing concerns about toxicity resulting from prolonged cycloph phosphamide therapy and has encouraged investigation of other therapeutic regimens.
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Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis
TL;DR: The presence of the same serologic marker in patients with kidney-limited and arteritis-associated necrotizing and crescentic glomerulonephritis, including Wegener's granulomatosis and polyarteritis nodosa, suggests that these clinically diverse diseases may have a similar pathogenesis, initiated by autoantibody-mediated activation of neutrophils.
Journal ArticleDOI
The Spectrum of Vasculitis: Clinical, Pathologic, Immunologic, and Therapeutic Considerations
TL;DR: In recent years, several of the more serious vasculitides, such as Wegener's granulomatosis and the systemic necrotizing vascultides of the polyarteritis nodosa group, have been shown to be extraordinarily responsive to chronic low-dose cytotoxic therapy, particularly cyclophosphamide.
Journal ArticleDOI
A Randomized, Double-Blind Study of Phenytoin for the Prevention of Post-Traumatic Seizures
TL;DR: Penytoin exerts a beneficial effect by reducing seizures only during the first week after severe head injury, and could not be attributed to differential mortality, low phenytoin levels, or treatment of some early seizures in patients assigned to the placebo group.